Gloria D. Coronado , John F. Dickerson , Amanda F. Petrik , Elva M Arredondo , Ming-Hsiang Tsou , Lourdes S. Martinez , Charisma L. Jenkins , Ana G. Rosales , Namrata Shivaprakash , Elizabeth Shuster , Jennifer L. Schneider , Jennifer S. Rivelli , Joanna G. Garcia , Juan A. Rodriguez , Katherine Mendoza , Jamie H. Thompson , Anne L. Escaron
{"title":"社区-诊所合作解决社会需求并改善结直肠癌筛查结果:PRIME阶梯形研究","authors":"Gloria D. Coronado , John F. Dickerson , Amanda F. Petrik , Elva M Arredondo , Ming-Hsiang Tsou , Lourdes S. Martinez , Charisma L. Jenkins , Ana G. Rosales , Namrata Shivaprakash , Elizabeth Shuster , Jennifer L. Schneider , Jennifer S. Rivelli , Joanna G. Garcia , Juan A. Rodriguez , Katherine Mendoza , Jamie H. Thompson , Anne L. Escaron","doi":"10.1016/j.cct.2025.108051","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>US colorectal cancer screening rates are suboptimal, particularly among Latino populations and patients served by federally qualified health centers (FQHCs). PRIME is a two-phased study to test effectiveness of a multi-component program to address patient social needs and improve colorectal cancer screening and follow-up in neighborhoods served by our partnering FQHC.</div></div><div><h3>Methods</h3><div>PRIME is a modified stepped-wedge study involving health-center patients in 12 neighborhoods in Southern California, followed by a scale-up study involving four additional health centers/neighborhoods. Eligible adults are ages 45–64, due for colorectal cancer screening, with a health center clinic visit in the previous 6 months. The intervention combines: (1) phone-based advance notification, a mailed FIT, and text messages with links to a short animated instructional video on FIT completion, (2) patient navigation for addressing patients' social needs, and (3) neighborhood-level events to raise awareness about the need for colorectal cancer screening.</div></div><div><h3>Results</h3><div>Recruitment for Phase I began in July 2024. Primary effectiveness outcome is receipt of any colorectal cancer screening within 6 months; primary implementation outcome is clinic-level and organizational-level rates of program delivery, by component (e.g., mailed FIT, social needs navigation, community events). Phase II scale-up activities will: use webinars, train-the-trainer workshops, and collaborative learning activities; and will assess adoption of and adaptations to the multi-component program.</div></div><div><h3>Conclusion</h3><div>This study will test the effectiveness, implementation, and scale-up of a multi-component video text message and social needs navigation program to improve colorectal cancer screening uptake in neighborhoods served by our partnering FQHC and community-based organizations.</div></div>","PeriodicalId":10636,"journal":{"name":"Contemporary clinical trials","volume":"157 ","pages":"Article 108051"},"PeriodicalIF":1.9000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Community-clinic partnership to address social needs and improve colorectal cancer screening outcomes: The PRIME stepped-wedge study\",\"authors\":\"Gloria D. Coronado , John F. Dickerson , Amanda F. Petrik , Elva M Arredondo , Ming-Hsiang Tsou , Lourdes S. Martinez , Charisma L. Jenkins , Ana G. Rosales , Namrata Shivaprakash , Elizabeth Shuster , Jennifer L. Schneider , Jennifer S. Rivelli , Joanna G. Garcia , Juan A. Rodriguez , Katherine Mendoza , Jamie H. Thompson , Anne L. Escaron\",\"doi\":\"10.1016/j.cct.2025.108051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>US colorectal cancer screening rates are suboptimal, particularly among Latino populations and patients served by federally qualified health centers (FQHCs). PRIME is a two-phased study to test effectiveness of a multi-component program to address patient social needs and improve colorectal cancer screening and follow-up in neighborhoods served by our partnering FQHC.</div></div><div><h3>Methods</h3><div>PRIME is a modified stepped-wedge study involving health-center patients in 12 neighborhoods in Southern California, followed by a scale-up study involving four additional health centers/neighborhoods. Eligible adults are ages 45–64, due for colorectal cancer screening, with a health center clinic visit in the previous 6 months. The intervention combines: (1) phone-based advance notification, a mailed FIT, and text messages with links to a short animated instructional video on FIT completion, (2) patient navigation for addressing patients' social needs, and (3) neighborhood-level events to raise awareness about the need for colorectal cancer screening.</div></div><div><h3>Results</h3><div>Recruitment for Phase I began in July 2024. Primary effectiveness outcome is receipt of any colorectal cancer screening within 6 months; primary implementation outcome is clinic-level and organizational-level rates of program delivery, by component (e.g., mailed FIT, social needs navigation, community events). Phase II scale-up activities will: use webinars, train-the-trainer workshops, and collaborative learning activities; and will assess adoption of and adaptations to the multi-component program.</div></div><div><h3>Conclusion</h3><div>This study will test the effectiveness, implementation, and scale-up of a multi-component video text message and social needs navigation program to improve colorectal cancer screening uptake in neighborhoods served by our partnering FQHC and community-based organizations.</div></div>\",\"PeriodicalId\":10636,\"journal\":{\"name\":\"Contemporary clinical trials\",\"volume\":\"157 \",\"pages\":\"Article 108051\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contemporary clinical trials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1551714425002459\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary clinical trials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1551714425002459","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Community-clinic partnership to address social needs and improve colorectal cancer screening outcomes: The PRIME stepped-wedge study
Background
US colorectal cancer screening rates are suboptimal, particularly among Latino populations and patients served by federally qualified health centers (FQHCs). PRIME is a two-phased study to test effectiveness of a multi-component program to address patient social needs and improve colorectal cancer screening and follow-up in neighborhoods served by our partnering FQHC.
Methods
PRIME is a modified stepped-wedge study involving health-center patients in 12 neighborhoods in Southern California, followed by a scale-up study involving four additional health centers/neighborhoods. Eligible adults are ages 45–64, due for colorectal cancer screening, with a health center clinic visit in the previous 6 months. The intervention combines: (1) phone-based advance notification, a mailed FIT, and text messages with links to a short animated instructional video on FIT completion, (2) patient navigation for addressing patients' social needs, and (3) neighborhood-level events to raise awareness about the need for colorectal cancer screening.
Results
Recruitment for Phase I began in July 2024. Primary effectiveness outcome is receipt of any colorectal cancer screening within 6 months; primary implementation outcome is clinic-level and organizational-level rates of program delivery, by component (e.g., mailed FIT, social needs navigation, community events). Phase II scale-up activities will: use webinars, train-the-trainer workshops, and collaborative learning activities; and will assess adoption of and adaptations to the multi-component program.
Conclusion
This study will test the effectiveness, implementation, and scale-up of a multi-component video text message and social needs navigation program to improve colorectal cancer screening uptake in neighborhoods served by our partnering FQHC and community-based organizations.
期刊介绍:
Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.