Bcl-2修饰因子（Bmf）： Bcl-2家族蛋白中的“神秘陌生人”

IF 15.4 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Death and Differentiation Pub Date : 2025-08-23 DOI:10.1038/s41418-025-01562-z

N. V. Pervushin, D. K. Nilov, B. Zhivotovsky, G. S. Kopeina

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引用次数: 0

摘要

Bcl-2家族成员是细胞命运的重要调节因子。其中一些（促凋亡）促进细胞死亡，而另一些（抗凋亡）支持细胞存活。Bcl-2修饰因子（Bmf）是bh3家族中广泛表达的蛋白，在许多正常组织和肿瘤组织中均有表达。Bmf的促凋亡活性在造血、配子发生、糖尿病、肿瘤发生等生理和病理过程中都是必不可少的。然而，Bmf多年来一直处于其他bh3蛋白的阴影之下。这篇综述旨在纠正这种不公正，阐明Bmf的多方面功能，它的调节，以及它在正常和病理背景下的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bcl-2 modifying factor (Bmf): “a mysterious stranger” in the Bcl-2 family proteins

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Bcl-2 modifying factor (Bmf): “a mysterious stranger” in the Bcl-2 family proteins

Members of the Bcl-2 family are essential regulators of cell fate. Some of them (proapoptotic) promote cell death, while others (antiapoptotic) support cell survival. Bcl-2 modifying factor (Bmf) is an understudied BH3-only protein of this family that is widely expressed in many normal and cancer tissues. Bmf’s proapoptotic activity is essential in physiological and pathological processes, including hematopoiesis, gametogenesis, diabetes, tumorigenesis, etc. However, Bmf has remained in the shadow of other BH3-only proteins for many years. This review aims to rectify this injustice and elucidate the multifaceted functions of Bmf, its regulation, and its significance in both normal and pathological contexts.

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来源期刊

Cell Death and Differentiation 生物-生化与分子生物学

CiteScore

24.70

自引率

1.60%

发文量

181

审稿时长

3 months

期刊介绍： Mission, vision and values of Cell Death & Differentiation: To devote itself to scientific excellence in the field of cell biology, molecular biology, and biochemistry of cell death and disease. To provide a unified forum for scientists and clinical researchers It is committed to the rapid publication of high quality original papers relating to these subjects, together with topical, usually solicited, reviews, meeting reports, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.