covid -19感染者大脑局灶性神经病变：炎症、原发性胶质血管衰竭和小胶质细胞功能障碍

IF 52.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-08-25 DOI:10.1038/s41392-025-02351-3

Peter Illes, Hai-Yan Yin, Yong Tang

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引用次数: 0

摘要

dameses和他的同事最近在《自然神经科学》上发表了一篇论文，记录了COVID的神经异常是基于大脑中的小胶质细胞功能障碍在感染COVID - 19的急性呼吸综合征病例中，中枢神经系统症状对疾病的严重程度有重要影响。作者使用了一个尸检平台，允许对从13名COVID和23名非COVID感染患者的大脑和外周器官制备的死后镜像块进行形态学和生化/分子生物学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction

查看原文本刊更多论文

Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction

Dénes and his co-workers recently published a paper in Nature Neuroscience, documenting that neurological abnormalities in COVID are based on microglial dysfunction in the brain.¹ In case of acute respiratory syndrome of COVID infection, the central nervous system symptomatology significantly contribute to the severity of this disease. The authors used an autopsy platform allowing morphological and biochemical/molecular biological investigations in postmortem mirror blocks prepared from the brain and peripheral organs of 13 COVID and 23 non- COVID-infected patients.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.