保卫基因组：泛素信号限制异染色质扩散

IF 52.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-08-21 DOI:10.1038/s41392-025-02349-x

Collin Bakker, Joanna Paulson, Nitika Taneja

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引用次数: 0

摘要

在最近发表在《科学》杂志上的一项研究中，Tiebang Kang和他的同事发现ASB7是通过靶向降解H3K9me3甲基转移酶SUV39H1来维持异染色质的关键负调控因子。这项工作揭示了细胞周期调节的染色质相关泛素连接酶回路，该回路维持表观遗传稳态，并揭示了癌症中可能被用于治疗的新脆弱性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fencing the genome: ubiquitin signaling restricts heterochromatin spread

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Fencing the genome: ubiquitin signaling restricts heterochromatin spread

In a recent study published in Science, Tiebang Kang and his colleagues¹ identify ASB7 as a key negative regulator of heterochromatin maintenance through targeted degradation of the H3K9me3 methyltransferase SUV39H1. The work uncovers a cell cycle-regulated chromatin-associated ubiquitin ligase circuit that maintains epigenetic homeostasis and reveals a novel vulnerability in cancer that may be exploited therapeutically.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.