坚持EAT-Lancet饮食、血浆蛋白质组学与慢性阻塞性肺疾病的风险

IF 7.7 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-08-24 DOI:10.1136/thorax-2025-223046

Xujia Lu, Yalong Pei, Yang Geng, Yulong Fan, Xinmei Lu, Lan Jiang, Yan Borné, Chaofu Ke

{"title":"坚持EAT-Lancet饮食、血浆蛋白质组学与慢性阻塞性肺疾病的风险","authors":"Xujia Lu, Yalong Pei, Yang Geng, Yulong Fan, Xinmei Lu, Lan Jiang, Yan Borné, Chaofu Ke","doi":"10.1136/thorax-2025-223046","DOIUrl":null,"url":null,"abstract":"Background and aims Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association. Methods This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform. Results Compared with individuals with the lowest adherence to the EAT-Lancet diet, those with higher adherence had a lower risk of developing COPD, and the HRs (95% CIs) for the highest adherence group versus the lowest were 0.607 (0.558 to 0.660) for the Willett EAT-Lancet index, 0.666 (0.593 to 0.748) for the Knuppel EAT-Lancet index, 0.586 (0.513 to 0.668) for the Stubbendorff EAT-Lancet index and 0.674 (0.620 to 0.732) for the Kesse-Guyot EAT-Lancet index. A total of 534, 149, 486 and 489 proteins showed significant mediation effects between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. The overall proteomic scores mediated 34.43% (95% CI: 22.86% to 53.45%), 24.15% (13.20% to 72.99%), 22.96% (14.53% to 41.13%) and 34.63% (21.26% to 60.38%) of the associations between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. Conclusion Higher adherence to the EAT-Lancet diet was associated with a lower risk of COPD, and a wide range of circulating plasma proteins mediated such association. Data may be obtained from a third party and are not publicly available. This study was conducted using the UK Biobank Resource under Application Number 60651. The data that support the findings of this study are available on application to the UK Biobank team at <http://www.ukbiobank.ac.uk/>.","PeriodicalId":23284,"journal":{"name":"Thorax","volume":"21 1","pages":""},"PeriodicalIF":7.7000,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adherence to the EAT-Lancet diet, plasma proteomics and the risk of chronic obstructive pulmonary disease\",\"authors\":\"Xujia Lu, Yalong Pei, Yang Geng, Yulong Fan, Xinmei Lu, Lan Jiang, Yan Borné, Chaofu Ke\",\"doi\":\"10.1136/thorax-2025-223046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and aims Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association. Methods This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform. Results Compared with individuals with the lowest adherence to the EAT-Lancet diet, those with higher adherence had a lower risk of developing COPD, and the HRs (95% CIs) for the highest adherence group versus the lowest were 0.607 (0.558 to 0.660) for the Willett EAT-Lancet index, 0.666 (0.593 to 0.748) for the Knuppel EAT-Lancet index, 0.586 (0.513 to 0.668) for the Stubbendorff EAT-Lancet index and 0.674 (0.620 to 0.732) for the Kesse-Guyot EAT-Lancet index. A total of 534, 149, 486 and 489 proteins showed significant mediation effects between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. The overall proteomic scores mediated 34.43% (95% CI: 22.86% to 53.45%), 24.15% (13.20% to 72.99%), 22.96% (14.53% to 41.13%) and 34.63% (21.26% to 60.38%) of the associations between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. Conclusion Higher adherence to the EAT-Lancet diet was associated with a lower risk of COPD, and a wide range of circulating plasma proteins mediated such association. Data may be obtained from a third party and are not publicly available. This study was conducted using the UK Biobank Resource under Application Number 60651. The data that support the findings of this study are available on application to the UK Biobank team at <http://www.ukbiobank.ac.uk/>.\",\"PeriodicalId\":23284,\"journal\":{\"name\":\"Thorax\",\"volume\":\"21 1\",\"pages\":\"\"},\"PeriodicalIF\":7.7000,\"publicationDate\":\"2025-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Thorax\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/thorax-2025-223046\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thorax","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/thorax-2025-223046","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

摘要

背景和目的坚持EAT-Lancet饮食已被观察到与降低各种疾病的风险相关。本研究旨在探讨坚持EAT-Lancet饮食与慢性阻塞性肺疾病（COPD）发病率的关系，并确定介导这种关系的血浆蛋白。方法：这项前瞻性研究纳入了来自UK Biobank的202340名基线时无COPD的参与者。通过四种不同的饮食指标来评估EAT-Lancet饮食的依从性。通过OLINK Explore-3072平台测量血浆蛋白信息，研究了21,186名参与者的血浆蛋白介导作用。结果与最低饮食依从性的个体相比，较高饮食依从性的个体患COPD的风险较低，最高饮食依从性组与最低饮食依从性组的hr （95% ci）分别为：Willett EAT-Lancet指数0.607（0.558 ~ 0.660）、Knuppel EAT-Lancet指数0.666（0.593 ~ 0.748）、Stubbendorff EAT-Lancet指数0.586（0.513 ~ 0.668）、kse - guyot EAT-Lancet指数0.674（0.620 ~ 0.732）。共有534、149、486和489个蛋白在Willett、Knuppel、Stubbendorff或Kesse-Guyot EAT-Lancet指数与COPD发病之间表现出显著的中介作用。总体蛋白质组学评分介导了Willett、Knuppel、Stubbendorff或Kesse-Guyot EAT-Lancet指数与COPD发病率之间34.43% （95% CI: 22.86% ~ 53.45%）、24.15%（13.20% ~ 72.99%）、22.96%（14.53% ~ 41.13%）和34.63%（21.26% ~ 60.38%）的相关性。结论：较高的EAT-Lancet饮食依从性与较低的COPD风险相关，并且广泛的循环血浆蛋白介导了这种关联。数据可能会从第三方获得，并且不会公开提供。本研究使用英国生物银行资源，申请号60651。支持本研究结果的数据可在英国生物银行团队的应用程序中获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Adherence to the EAT-Lancet diet, plasma proteomics and the risk of chronic obstructive pulmonary disease

Background and aims Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association. Methods This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform. Results Compared with individuals with the lowest adherence to the EAT-Lancet diet, those with higher adherence had a lower risk of developing COPD, and the HRs (95% CIs) for the highest adherence group versus the lowest were 0.607 (0.558 to 0.660) for the Willett EAT-Lancet index, 0.666 (0.593 to 0.748) for the Knuppel EAT-Lancet index, 0.586 (0.513 to 0.668) for the Stubbendorff EAT-Lancet index and 0.674 (0.620 to 0.732) for the Kesse-Guyot EAT-Lancet index. A total of 534, 149, 486 and 489 proteins showed significant mediation effects between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. The overall proteomic scores mediated 34.43% (95% CI: 22.86% to 53.45%), 24.15% (13.20% to 72.99%), 22.96% (14.53% to 41.13%) and 34.63% (21.26% to 60.38%) of the associations between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. Conclusion Higher adherence to the EAT-Lancet diet was associated with a lower risk of COPD, and a wide range of circulating plasma proteins mediated such association. Data may be obtained from a third party and are not publicly available. This study was conducted using the UK Biobank Resource under Application Number 60651. The data that support the findings of this study are available on application to the UK Biobank team at .

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.