Rufus Akinyemi, Olabode Omotoso, Lwere Kamada, David Ndetei, Michael Cuccaro, Albert Akpalu, Larry D. Adams, Stephen F. Sarfo, Alfred K. Njamnshi, Patrice Whitehead, Njideka Okubadejo, Mena Pedro Ramon, Albertino Damasceno, Scott Williams, Biniyam Ayele, Yared Zenebe, Thierry Adokounou, Jean Ikanga, Judith Boshe, Joshua Akinyemi, Olufisayo Elugbadebo, Reginald Obiako, Kolawole Wahab, Emmanuel Iwuozo, Kazeem Akinwande, Stella-Marie Paddick, Mayowa Ogunronbi, Christine Musyimi, Anyamele Ibuchim, Gabriel Ogunde, Motunrayo Coker, Olaleye Adeniji, Eniola Cadmus, Oladotun Olalusi, Timothy Ciesielski, Paul Nwani, Susan Halloran Blanton, Paul Olowoyo, Oluwadamilola Ojo, Rasaq Durodoye, Godwin Osaigbovo, Noeline Nakasujja, Mlaki Damas Andrea, Akinsola Ojagbemi, Godwin Ogbole, Temitope Farombi, Adefolakemi T. Ogundele, Azizi Seixas, Lawrence Adebusoye, Michelle Nichols, Ernest O. Nwazor, Nosakhare Osemwegie, Maeleen Guerchet, Farid Rajabli, Olufemi Olowookere, Jacob L. McCauley, Oyedunni Arulogun, Sudha Seshadri, Mayowa Owolabi, Guiseppe Tosto, Goldie Byrd, Richard Walker, Christiane Reitz, William Bush, Olusegun Baiyewu, Anthony J. Griswold, Brian W. Kunkle, Jonathan Haines, Rajesh N. Kalaria, Jeffery M. Vance, Adesola Ogunniyi, Margaret Pericak-Vance
{"title":"ADSP中阿尔茨海默病多样性遗传队列的招募和保留（read -ADSP）：一项确定阿尔茨海默病遗传因素的全球努力","authors":"Rufus Akinyemi, Olabode Omotoso, Lwere Kamada, David Ndetei, Michael Cuccaro, Albert Akpalu, Larry D. Adams, Stephen F. Sarfo, Alfred K. Njamnshi, Patrice Whitehead, Njideka Okubadejo, Mena Pedro Ramon, Albertino Damasceno, Scott Williams, Biniyam Ayele, Yared Zenebe, Thierry Adokounou, Jean Ikanga, Judith Boshe, Joshua Akinyemi, Olufisayo Elugbadebo, Reginald Obiako, Kolawole Wahab, Emmanuel Iwuozo, Kazeem Akinwande, Stella-Marie Paddick, Mayowa Ogunronbi, Christine Musyimi, Anyamele Ibuchim, Gabriel Ogunde, Motunrayo Coker, Olaleye Adeniji, Eniola Cadmus, Oladotun Olalusi, Timothy Ciesielski, Paul Nwani, Susan Halloran Blanton, Paul Olowoyo, Oluwadamilola Ojo, Rasaq Durodoye, Godwin Osaigbovo, Noeline Nakasujja, Mlaki Damas Andrea, Akinsola Ojagbemi, Godwin Ogbole, Temitope Farombi, Adefolakemi T. Ogundele, Azizi Seixas, Lawrence Adebusoye, Michelle Nichols, Ernest O. Nwazor, Nosakhare Osemwegie, Maeleen Guerchet, Farid Rajabli, Olufemi Olowookere, Jacob L. McCauley, Oyedunni Arulogun, Sudha Seshadri, Mayowa Owolabi, Guiseppe Tosto, Goldie Byrd, Richard Walker, Christiane Reitz, William Bush, Olusegun Baiyewu, Anthony J. Griswold, Brian W. Kunkle, Jonathan Haines, Rajesh N. Kalaria, Jeffery M. Vance, Adesola Ogunniyi, Margaret Pericak-Vance","doi":"10.1002/trc2.70148","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Alzheimer's disease (AD) remains a major neurocognitive disorder of global health significance. Globalizing ancestral diversity in AD genetics is essential to identify causal variants, improve diagnosis, and enable equitable therapeutic interventions across populations. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) initiative addresses this by including African ancestry and Hispanic/Latinx (HL) ancestry populations.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>READD-ADSP, a case–control study, aims to recruit, evaluate, and retain 13,000 participants: 5000 Indigenous Africans, 4000 African Americans, and 4000 Hispanic/Latinix individuals. In Africa, recruitment involves nine sub-Saharan African countries under the African Dementia Consortium, and with protocols ensuring standardized data collection, phenotype harmonization, culturally informed diagnostic algorithms, and robust community engagement.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Study pparticipants are recruited, ascertained and retained. Blood samples and fractions (DNA, plasma, RNA) are biobanked for genomic, epigenomic, proteomic, and transcriptomic analyses.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>This study will advance precision ADRD medicine and establish a model for working with diverse global cohorts of brain disorders.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) addresses critical gaps in Alzheimer's Disease and Related Dementias (ADRD) research by including underrepresented groups.</li>\n \n <li>The study recruits 13,000 participants of African, African American, and Hispanic/Latinx ancestries.</li>\n \n <li>Standardized protocols enable rigorous phenotyping and harmonization across diverse populations.</li>\n \n <li>Findings will inform precision medicine and reduce health disparities in ADRD outcomes.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 3","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70148","citationCount":"0","resultStr":"{\"title\":\"Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP): A global effort to identify genetic factors in Alzheimer's disease\",\"authors\":\"Rufus Akinyemi, Olabode Omotoso, Lwere Kamada, David Ndetei, Michael Cuccaro, Albert Akpalu, Larry D. Adams, Stephen F. Sarfo, Alfred K. Njamnshi, Patrice Whitehead, Njideka Okubadejo, Mena Pedro Ramon, Albertino Damasceno, Scott Williams, Biniyam Ayele, Yared Zenebe, Thierry Adokounou, Jean Ikanga, Judith Boshe, Joshua Akinyemi, Olufisayo Elugbadebo, Reginald Obiako, Kolawole Wahab, Emmanuel Iwuozo, Kazeem Akinwande, Stella-Marie Paddick, Mayowa Ogunronbi, Christine Musyimi, Anyamele Ibuchim, Gabriel Ogunde, Motunrayo Coker, Olaleye Adeniji, Eniola Cadmus, Oladotun Olalusi, Timothy Ciesielski, Paul Nwani, Susan Halloran Blanton, Paul Olowoyo, Oluwadamilola Ojo, Rasaq Durodoye, Godwin Osaigbovo, Noeline Nakasujja, Mlaki Damas Andrea, Akinsola Ojagbemi, Godwin Ogbole, Temitope Farombi, Adefolakemi T. Ogundele, Azizi Seixas, Lawrence Adebusoye, Michelle Nichols, Ernest O. Nwazor, Nosakhare Osemwegie, Maeleen Guerchet, Farid Rajabli, Olufemi Olowookere, Jacob L. 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Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP): A global effort to identify genetic factors in Alzheimer's disease
INTRODUCTION
Alzheimer's disease (AD) remains a major neurocognitive disorder of global health significance. Globalizing ancestral diversity in AD genetics is essential to identify causal variants, improve diagnosis, and enable equitable therapeutic interventions across populations. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) initiative addresses this by including African ancestry and Hispanic/Latinx (HL) ancestry populations.
METHODS
READD-ADSP, a case–control study, aims to recruit, evaluate, and retain 13,000 participants: 5000 Indigenous Africans, 4000 African Americans, and 4000 Hispanic/Latinix individuals. In Africa, recruitment involves nine sub-Saharan African countries under the African Dementia Consortium, and with protocols ensuring standardized data collection, phenotype harmonization, culturally informed diagnostic algorithms, and robust community engagement.
RESULTS
Study pparticipants are recruited, ascertained and retained. Blood samples and fractions (DNA, plasma, RNA) are biobanked for genomic, epigenomic, proteomic, and transcriptomic analyses.
DISCUSSION
This study will advance precision ADRD medicine and establish a model for working with diverse global cohorts of brain disorders.
Highlights
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) addresses critical gaps in Alzheimer's Disease and Related Dementias (ADRD) research by including underrepresented groups.
The study recruits 13,000 participants of African, African American, and Hispanic/Latinx ancestries.
Standardized protocols enable rigorous phenotyping and harmonization across diverse populations.
Findings will inform precision medicine and reduce health disparities in ADRD outcomes.
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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