Correlation between estimated glucose disposal rate and the short-term thrombolytic prognosis of patients with acute cerebral infarction

Objective

To investigate the correlation between the estimated glucose disposal rate (eGDR) and the short-term thrombolytic prognosis of patients with acute cerebral infarction.

Methods

A total of 214 patients with acute cerebral infarction who received thrombolytic treatment in our hospital from January 2022 to December 2023 were selected. The clinical data of the patients were collected, including general conditions, laboratory tests, etc. The eGDR was calculated using the homeostasis model assessment method and divided into four groups according to the quartiles of eGDR. The differences in clinical data among the groups were compared. According to the prognosis of the patients after thrombolysis, they were divided into the favorable functional outcome (modified Rankin scale 0–2 points) and the poor functional outcome group (modified Rankin scale 3–6 points). The eGDR and other clinical indicators of the two groups of patients were compared. Finally, univariate and multivariate analyses were used to evaluate the correlation between eGDR and related results.

Results

The median value of eGDR was 7.07 mg/kg/min (interquartile range, 6.15–9.23). Among them, the history of diabetes, BMI, HbA1c, triglycerides, and fasting blood glucose had statistical differences in the four subgroups (P < 0.05). The eGDR of the patients in the good prognosis group was significantly higher than that in the poor prognosis group (P < 0.05), while the systolic blood pressure, BMI, HbA1c, fasting blood glucose, NIHSS score at admission, and mRS score at admission were all lower than those in the poor prognosis group (P < 0.05). Multivariate Logistic regression analysis showed that the hemorrhagic transformation rate in the low eGDR group was still significantly higher than that in the high eGDR group (adjusted OR 1.24, [95 %CI: 1.02–1.45; p < 0.01]); the rates of favorable functional outcome (mRS score 0–2 points) and excellent functional outcome (mRS score 0–1 points) had statistical differences, and the high eGDR group was significantly higher than the low eGDR group. However, the rate of worse ending or death did not show a statistical difference.

Conclusion

eGDR is closely related to the thrombolytic prognosis of patients with acute cerebral infarction and can be used as an important indicator for evaluating the prognosis of patients.