Alessandro Di Spiezio, Marta Gómez-Gonzalo, Angela Chiavegato, Micaela Zonta
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Recent Insights on Supraspinal Astrocytes in Chronic Pain
Chronic pain is a debilitating, life-altering condition that affects a significant portion of the global population, impacting approximately one fifth of people in Europe and one third of people worldwide. Clinical and experimental efforts are increasingly converging to deepen our comprehension of the molecular, cellular and circuit-level mechanisms underlying persistent pain. While most studies have traditionally focused on alterations of nociceptive pathways in neurons, growing evidence highlights the critical role of astrocytes in modulating these pathways and contributing to the development of the central sensitization that characterizes chronic pain. Moreover, astrocytes are also implicated in pain-associated maladaptive behaviours and cognitive impairments. In this context, we review the latest findings on astrocyte involvement in chronic pain and its related mood and cognitive comorbidities.
Graphical Abstract
Created in BioRender. Chiavegato, A. (2025). https://BioRender.com/42hblyi
期刊介绍：
Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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