舟状骨和桡骨远端骨密度的年龄相关变化：定量计算机断层扫描研究

IF 3.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2025-08-18 DOI:10.1016/j.bone.2025.117612

Ryutaro Iwasaki , Yusuke Matsuura , Takahiro Yamazaki , Kaoru Kitsukawa , Aya Kanazuka , Seiji Ohtori

{"title":"舟状骨和桡骨远端骨密度的年龄相关变化：定量计算机断层扫描研究","authors":"Ryutaro Iwasaki , Yusuke Matsuura , Takahiro Yamazaki , Kaoru Kitsukawa , Aya Kanazuka , Seiji Ohtori","doi":"10.1016/j.bone.2025.117612","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Scaphoid fractures predominantly occur in young males, while distal radius fractures occur in elderly females, despite similar injury mechanisms. We hypothesized that age-related bone mineral density (BMD) changes differ between these bones, explaining their distinct fracture patterns. This study compared age-related BMD changes between the scaphoid and distal radius using quantitative computed tomography (qCT).</div></div><div><h3>Methods</h3><div>We analyzed 167 cases (110 males, 57 females; mean age 45.2 ± 18.1 years) who underwent qCT including forearm and carpal bones. Exclusion criteria included fractures, arthritis, and implants. BMD was measured separately for cortical and cancellous bone in both the scaphoid and distal radius using phantom-corrected Hounsfield values. Correlations between age and BMD were evaluated using Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>The distal radius showed significant negative correlation with age in overall BMD (<em>r</em> = −0.44) and cancellous BMD (<em>r</em> = −0.40), while the scaphoid showed no significant correlation. Females demonstrated significantly stronger negative correlations than males in both bones. Age-related BMD decline occurred predominantly in cancellous bone. The radius/scaphoid BMD ratio decreased with age (<em>r</em> = −0.51), indicating relatively greater BMD decline in the radius.</div></div><div><h3>Conclusion</h3><div>The distal radius exhibits stronger age-related BMD decline than the scaphoid, particularly in cancellous bone. This differential aging pattern may explain why scaphoid fractures predominate in young individuals while distal radius fractures are more common in the elderly.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117612"},"PeriodicalIF":3.6000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related changes in bone mineral density of the scaphoid and distal radius: A quantitative computed tomography study\",\"authors\":\"Ryutaro Iwasaki , Yusuke Matsuura , Takahiro Yamazaki , Kaoru Kitsukawa , Aya Kanazuka , Seiji Ohtori\",\"doi\":\"10.1016/j.bone.2025.117612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Scaphoid fractures predominantly occur in young males, while distal radius fractures occur in elderly females, despite similar injury mechanisms. We hypothesized that age-related bone mineral density (BMD) changes differ between these bones, explaining their distinct fracture patterns. This study compared age-related BMD changes between the scaphoid and distal radius using quantitative computed tomography (qCT).</div></div><div><h3>Methods</h3><div>We analyzed 167 cases (110 males, 57 females; mean age 45.2 ± 18.1 years) who underwent qCT including forearm and carpal bones. Exclusion criteria included fractures, arthritis, and implants. BMD was measured separately for cortical and cancellous bone in both the scaphoid and distal radius using phantom-corrected Hounsfield values. Correlations between age and BMD were evaluated using Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>The distal radius showed significant negative correlation with age in overall BMD (<em>r</em> = −0.44) and cancellous BMD (<em>r</em> = −0.40), while the scaphoid showed no significant correlation. Females demonstrated significantly stronger negative correlations than males in both bones. Age-related BMD decline occurred predominantly in cancellous bone. The radius/scaphoid BMD ratio decreased with age (<em>r</em> = −0.51), indicating relatively greater BMD decline in the radius.</div></div><div><h3>Conclusion</h3><div>The distal radius exhibits stronger age-related BMD decline than the scaphoid, particularly in cancellous bone. This differential aging pattern may explain why scaphoid fractures predominate in young individuals while distal radius fractures are more common in the elderly.</div></div>\",\"PeriodicalId\":9301,\"journal\":{\"name\":\"Bone\",\"volume\":\"200 \",\"pages\":\"Article 117612\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bone\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S8756328225002248\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bone","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S8756328225002248","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

背景舟状骨骨折主要发生在年轻男性，而桡骨远端骨折发生在老年女性，尽管损伤机制相似。我们假设这些骨骼与年龄相关的骨密度（BMD）变化不同，解释了它们不同的骨折模式。本研究使用定量计算机断层扫描（qCT）比较了舟状骨和桡骨远端与年龄相关的骨密度变化。方法167例（男110例，女57例，平均年龄45.2±18.1岁）行前臂、腕骨qCT检查。排除标准包括骨折、关节炎和植入物。使用幻影校正的Hounsfield值分别测量舟状骨和桡骨远端皮质骨和松质骨的骨密度。使用Pearson相关系数评估年龄与骨密度之间的相关性。结果桡骨远端骨密度与年龄呈显著负相关（r = - 0.44），松质骨骨密度与年龄呈显著负相关（r = - 0.40），舟状骨与年龄无显著相关。女性在这两种骨骼上的负相关性明显强于男性。年龄相关性骨密度下降主要发生在松质骨。桡骨/舟骨骨密度比随着年龄的增长而下降（r = - 0.51），表明桡骨骨密度下降相对较大。结论桡骨远端比舟骨表现出更强的年龄相关性骨密度下降，尤其是松质骨。这种不同的衰老模式可以解释为什么舟状骨骨折在年轻人中占主导地位，而桡骨远端骨折在老年人中更常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Age-related changes in bone mineral density of the scaphoid and distal radius: A quantitative computed tomography study

Background

Scaphoid fractures predominantly occur in young males, while distal radius fractures occur in elderly females, despite similar injury mechanisms. We hypothesized that age-related bone mineral density (BMD) changes differ between these bones, explaining their distinct fracture patterns. This study compared age-related BMD changes between the scaphoid and distal radius using quantitative computed tomography (qCT).

Methods

We analyzed 167 cases (110 males, 57 females; mean age 45.2 ± 18.1 years) who underwent qCT including forearm and carpal bones. Exclusion criteria included fractures, arthritis, and implants. BMD was measured separately for cortical and cancellous bone in both the scaphoid and distal radius using phantom-corrected Hounsfield values. Correlations between age and BMD were evaluated using Pearson correlation coefficients.

Results

The distal radius showed significant negative correlation with age in overall BMD (r = −0.44) and cancellous BMD (r = −0.40), while the scaphoid showed no significant correlation. Females demonstrated significantly stronger negative correlations than males in both bones. Age-related BMD decline occurred predominantly in cancellous bone. The radius/scaphoid BMD ratio decreased with age (r = −0.51), indicating relatively greater BMD decline in the radius.

Conclusion

The distal radius exhibits stronger age-related BMD decline than the scaphoid, particularly in cancellous bone. This differential aging pattern may explain why scaphoid fractures predominate in young individuals while distal radius fractures are more common in the elderly.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.