Xiaoyu Tai, Tao Luo, Keying Song, Hui Zhao, Silu Chen, Huiqin Li, Min Liu, Jianghong Dai, Xu Qian, Mulong Du
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The dietary pattern of garlic, including the frequency of consuming garlic, garlic intake, and garlic preference information, was collected using a food questionnaire for each cohort. Logistic regression and structural equation modeling were used to assess the effect of garlic consumption on five common chronic diseases, which comprised cancer, diabetes, hypertension, respiratory diseases, and cardiovascular disease (CVD).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In the CLHLS cohort, individuals who consumed garlic almost every day had a significantly lower risk of five of the most common chronic diseases (cancer: odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.30–0.81, <i>p</i> = 0.006; diabetes: OR = 0.58, 95% CI = 0.43–0.76, <i>p</i> < 0.001; hypertension: OR = 0.68, 95% CI = 0.61–0.77, <i>p</i> < 0.001; respiratory diseases: OR = 0.77, 95% CI = 0.67–0.87, <i>p</i> < 0.001; and CVD: OR = 0.69, 95% CI = 0.59–0.80, <i>p</i> < 0.001). Similarly, in the XMC, there was a consistent protective effect of high garlic intake on hypertension, respiratory diseases and CVD. Additionally, in the UKBB cohort, individuals who liked garlic had a decreased risk of diabetes and CVD. Notably, in three cohorts, structural equation modeling results showed that there was a significant protective total effect of garlic consumption on the five common chronic diseases.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>A high garlic consumption is associated with a reduced risk of chronic diseases. Our findings highlight the potential protective role of garlic in preventing chronic diseases.</p>\n </section>\n </div>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"4 4","pages":"269-280"},"PeriodicalIF":3.3000,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.70030","citationCount":"0","resultStr":"{\"title\":\"Dietary Pattern of Garlic and Risk of Chronic Diseases: Evidence From Three Large-Scale Cohorts\",\"authors\":\"Xiaoyu Tai, Tao Luo, Keying Song, Hui Zhao, Silu Chen, Huiqin Li, Min Liu, Jianghong Dai, Xu Qian, Mulong Du\",\"doi\":\"10.1002/hcs2.70030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases. This study aimed to examine the association between garlic consumption and the risk of chronic diseases.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We included 26,524 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) with data of the frequency of garlic consumption, 7658 participants from the Xinjiang multiethnic cohort (XMC) study with data of garlic intake, and 141,684 participants from the UK Biobank (UKBB) with data of the preference for garlic. The dietary pattern of garlic, including the frequency of consuming garlic, garlic intake, and garlic preference information, was collected using a food questionnaire for each cohort. Logistic regression and structural equation modeling were used to assess the effect of garlic consumption on five common chronic diseases, which comprised cancer, diabetes, hypertension, respiratory diseases, and cardiovascular disease (CVD).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>In the CLHLS cohort, individuals who consumed garlic almost every day had a significantly lower risk of five of the most common chronic diseases (cancer: odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.30–0.81, <i>p</i> = 0.006; diabetes: OR = 0.58, 95% CI = 0.43–0.76, <i>p</i> < 0.001; hypertension: OR = 0.68, 95% CI = 0.61–0.77, <i>p</i> < 0.001; respiratory diseases: OR = 0.77, 95% CI = 0.67–0.87, <i>p</i> < 0.001; and CVD: OR = 0.69, 95% CI = 0.59–0.80, <i>p</i> < 0.001). Similarly, in the XMC, there was a consistent protective effect of high garlic intake on hypertension, respiratory diseases and CVD. 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引用次数: 0
摘要
背景了解大蒜与慢性疾病的关系有助于提高预防和减轻疾病负担。这项研究旨在研究大蒜消费与慢性疾病风险之间的关系。方法纳入中国健康长寿纵向调查（CLHLS）中含有大蒜食用频率数据的26524名受试者，新疆多民族队列研究（XMC）中含有大蒜摄入数据的7658名受试者，以及英国生物银行（UKBB）中含有大蒜偏好数据的141684名受试者。每个队列使用食物问卷收集大蒜的饮食模式，包括食用大蒜的频率、大蒜摄入量和大蒜偏好信息。采用Logistic回归和结构方程模型评估大蒜消费对五种常见慢性疾病（包括癌症、糖尿病、高血压、呼吸系统疾病和心血管疾病）的影响。结果在CLHLS队列中，几乎每天食用大蒜的个体患五种最常见慢性疾病的风险显著降低(癌症：优势比[OR] = 0.51, 95%可信区间[CI] = 0.30-0.81, p = 0.006；糖尿病：OR = 0.58, 95% CI = 0.43-0.76, p < 0.001；高血压：OR = 0.68, 95% CI = 0.61-0.77, p < 0.001；呼吸系统疾病：OR = 0.77, 95% CI = 0.67-0.87, p < 0.001；和心血管疾病:= 0.69,95% CI -0.80 = 0.59, p & lt; 0.001)。同样，在XMC中，高大蒜摄入量对高血压、呼吸系统疾病和心血管疾病有一致的保护作用。此外，在UKBB队列中，喜欢大蒜的人患糖尿病和心血管疾病的风险降低。值得注意的是，在三个队列中，结构方程建模结果显示，大蒜食用对五种常见慢性疾病有显著的保护作用。结论：大蒜的高摄入量与慢性疾病风险的降低有关。我们的研究结果强调了大蒜在预防慢性疾病方面的潜在保护作用。
Dietary Pattern of Garlic and Risk of Chronic Diseases: Evidence From Three Large-Scale Cohorts
Background
Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases. This study aimed to examine the association between garlic consumption and the risk of chronic diseases.
Methods
We included 26,524 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) with data of the frequency of garlic consumption, 7658 participants from the Xinjiang multiethnic cohort (XMC) study with data of garlic intake, and 141,684 participants from the UK Biobank (UKBB) with data of the preference for garlic. The dietary pattern of garlic, including the frequency of consuming garlic, garlic intake, and garlic preference information, was collected using a food questionnaire for each cohort. Logistic regression and structural equation modeling were used to assess the effect of garlic consumption on five common chronic diseases, which comprised cancer, diabetes, hypertension, respiratory diseases, and cardiovascular disease (CVD).
Results
In the CLHLS cohort, individuals who consumed garlic almost every day had a significantly lower risk of five of the most common chronic diseases (cancer: odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.30–0.81, p = 0.006; diabetes: OR = 0.58, 95% CI = 0.43–0.76, p < 0.001; hypertension: OR = 0.68, 95% CI = 0.61–0.77, p < 0.001; respiratory diseases: OR = 0.77, 95% CI = 0.67–0.87, p < 0.001; and CVD: OR = 0.69, 95% CI = 0.59–0.80, p < 0.001). Similarly, in the XMC, there was a consistent protective effect of high garlic intake on hypertension, respiratory diseases and CVD. Additionally, in the UKBB cohort, individuals who liked garlic had a decreased risk of diabetes and CVD. Notably, in three cohorts, structural equation modeling results showed that there was a significant protective total effect of garlic consumption on the five common chronic diseases.
Conclusions
A high garlic consumption is associated with a reduced risk of chronic diseases. Our findings highlight the potential protective role of garlic in preventing chronic diseases.
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