环状RNA和n6 -甲基腺苷修饰在结直肠癌中的研究进展

IF 2.4 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-08-18 DOI:10.1016/j.gene.2025.149684

Jiamei Xu , Jin Liu , Fengxia Huang , Zhouzhou Chao , Jiayao Chen , Aijing Xu , Hua Zhang , Wei Zhu

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引用次数: 0

摘要

环状RNA （circRNA）和n6 -甲基腺苷（m6A）甲基化修饰在癌症研究领域备受关注。环状RNA是一类共价闭环非编码RNA (ncRNA)，在细胞质中大量表达。这些分子表现出显著的进化保守性和卓越的稳定性，使它们成为调节功能的理想候选者。这些独特的特性使circRNA在结直肠癌（CRC）中发挥作用，包括基因表达和肿瘤细胞生物学的调节。m6A修饰是真核信使RNA （mRNA）和ncRNA最常见的修饰之一。这种动态修饰系统几乎参与了circRNA代谢的所有方面，包括生物发生、细胞内运输和周转。同时，circRNA的生物学功能可参与调控m6A相关酶的表达。本文主要综述了circRNA和m6A修饰之间的相互作用，特别强调了它们在CRC发病和进展中的共同影响。

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Research progress of circular RNA and N6-methyladenosine modification in colorectal cancer

Circular RNA (circRNA) and N6-methyladenosine (m6A) methylation modification have attracted much attention in the field of cancer research. CircRNAs represent a class of covalently closed-loop non-coding RNA (ncRNA) that are abundantly expressed in the cytoplasm. These molecules exhibit remarkable evolutionary conservation and exceptional stability, making them ideal candidates for regulatory functions. These unique properties enable circRNA to play a role in colorectal cancer (CRC), including modulation of gene expression and tumor cell biology. m6A modification is one of the most common modifications of eukaryotic messenger RNA (mRNA) and ncRNA. This dynamic modification system participates in virtually all aspects of circRNA metabolism, including biogenesis, intracellular trafficking, and turnover. At the same time, the biological function of circRNA can be involved in the regulation of the expression of m6A related enzymes. This review mainly reviews the interaction between circRNA and m6A modification, with particular emphasis on and their collective impact on CRC pathogenesis and progression.

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.