红红草苷通过下调补体C3-C3aR通路介导的小胶质细胞和星形胶质细胞的激活来减轻大鼠癫痫和认知功能障碍

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Manqian Huang, Meiling Tang, Lu Liu
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引用次数: 0

摘要

癫痫是一种慢性神经系统疾病,其特征是异常的神经放电,可导致认知障碍。红景天苷(Sal)是一种生物活性成分,可保护神经元免受各种损伤。本研究旨在探索Sal在癫痫中的治疗潜力,并阐明其作用机制。采用戊四唑点燃法建立大鼠癫痫持续状态(SE)模型。用Sal治疗SE大鼠。评估发作潜伏期和癫痫分期评分。采用新颖的物体识别实验和Morris水迷宫实验评价大鼠的认知功能。检查神经元损伤和海马病理,以及小胶质细胞和星形胶质细胞活化,补体C3-C3a受体(C3-C3aR)通路参与和炎症因子水平。与未经治疗的SE大鼠相比,癫痫发作潜伏期延长,癫痫分期评分降低,认知能力提高。此外,Sal抑制了C3-C3ar、小胶质细胞和星形胶质细胞的激活,同时降低了炎症因子的水平,从而改善了海马损伤和神经元丢失。Sal可能通过下调补体C3-C3aR通路介导的小胶质细胞和星形胶质细胞的激活来减轻癫痫和认知功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes

Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes

Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes

Epilepsy is a chronic neurological disorder featured by abnormal neural discharges that can lead to cognitive impairment. Salidroside (Sal), a biologically active component, protects neurons against various insults. The current study aims to explore the therapeutic potential of Sal in epilepsy and elucidate the mechanisms underlying its effects. We established a rat model of status epilepticus (SE) using pentylenetetrazol-kindling. SE rats were treated with Sal. Assessment of seizure latency and epileptic stage scores were performed. Cognitive function of rats was evaluated using a novel object recognition test and a Morris water maze test. Neuronal damage and hippocampal pathology were examined, alongside microglial and astrocyte activation, complement C3-C3a receptor (C3-C3aR) pathway involvement, and inflammatory factor levels. Sal prolonged seizure latency, decreased epilepsy stage scores, and improved cognitive performance compared to untreated SE rats. Furthermore, Sal suppressed the activation of C3-C3ar, microglia, and astrocytes, while decreasing the levels of inflammatory factors, which ameliorated hippocampal damage and neuronal loss. Sal may attenuate epilepsy and cognitive dysfunction by downregulating complement C3-C3aR pathway-mediated activation of microglia and astrocytes.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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