神经胶质微量胺相关受体1 (TAAR1)和微生物群在精神分裂症中的作用

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Vassiliy Tsytsarev, Anastasia N. Vaganova, Anna Volnova, Zoia Fesenko, Bruk Getachew, Raul R. Gainetdinov, Yousef Tizabi
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引用次数: 0

摘要

微量胺相关受体(TAARs)是一类G蛋白偶联受体,对氨基酸的代谢衍生物如苯丙氨酸、酪氨酸和色氨酸有反应。与母体化合物或其他单胺类神经递质(如多巴胺、去甲肾上腺素或血清素)相比,它们在外周神经系统和中枢神经系统(CNS)中的浓度非常低,因此得名微量胺。遗传、药理学和神经生物学研究已经将TAAR1(研究最多的TAARs受体)与精神分裂症(SCZ)的病理生理联系起来,目前的治疗方法有限。该领域的最新进展涉及神经胶质-微生物群相互作用在SCZ病理生理。TAAR1与神经胶质细胞和肠道微生物群(GM)的相互作用使其成为SCZ的新靶点。在这篇综述中,在简要介绍了已知的SCZ神经生物学底物之后,我们深入探讨了胶质细胞的具体作用,包括公开转录组数据的分析,它们与GM的相互作用以及TAAR1在与SCZ相关的胶质-GM信号传导中的潜在整合作用。最后,我们建议如何利用TAAR1操纵来治疗这种毁灭性的神经精神疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Glial Trace Amine Associated Receptor 1 (TAAR1) and Microbiota in Schizophrenia

Trace amine-associated receptors (TAARs) are a class of G protein-coupled receptors that respond to metabolic derivatives of the amino acids such as phenylalanine, tyrosine, and tryptophan. Trace amines derive their name from the fact that their concentration in the periphery as well as in the central nervous system (CNS) is in trace amounts compared to the parent compound or other monoamine neurotransmitters such as dopamine, norepinephrine, or serotonin. Genetic, pharmacological and neurobiological studies have linked TAAR1, the most studied receptor of the TAARs to the pathophysiology of schizophrenia (SCZ), the current treatments of which are limited. Recent developments in the field implicate glial-microbiota interactions in SCZ pathophysiology. TAAR1 interactions with the glial cells and the gut microbiota (GM) makes it a suitable candidate as a novel target in SCZ. In this review, following brief descriptions of the known neurobiological substrates of SCZ, we delve into the specific roles of glial cells, including analysis of the public transcriptomic data, their interaction with GM and the potential integrator role of TAAR1 in glial-GM signaling relevant to SCZ. Finally, we suggest how TAAR1 manipulation may be exploited in this devastating neuropsychiatric disorder.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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