S. Karthi , T. Ramalingam , R. Iyswarya , D. Arul Kumar
{"title":"QDCRNet:利用基因表达数据进行病毒检测的量子扩展卷积循环网络","authors":"S. Karthi , T. Ramalingam , R. Iyswarya , D. Arul Kumar","doi":"10.1016/j.compbiolchem.2025.108625","DOIUrl":null,"url":null,"abstract":"<div><div>Viral Infections cause several common human illnesses, like the common cold, flu, mouth blisters, and chickenpox. However, numerous viruses, including rabies, hepatitis, Ebola, avian flu, and coronavirus cause significant health risks due to their high transmission rates. Infections are obligate intracellular parasites that depend on host cellular organisms, resources, and replication for their reproduction and spread. Timely and precise identification of these viruses is vital for appropriate treatment and preventing further spread. However common challenges such as, non-specific symptoms, variability in viral expression, and delayed testing often complicate timely diagnosis. To address this issue, a powerful module named Quantum Dilated Convolutional Recurrent Network (QDCRNet) has been developed for virus detection. Firstly, gene expression data is given into data transformation, and it is done by the Box-Cox transformation. Then, Feature Selection (FS) is performed using Gower distance and mutual information to select the virus-affected region. Finally, detection of the virus is done using QDCRNet, which is the integration of Quantum Dilated Convolutional Neural Network (QDCNN) and Deep Recurrent Neural Network (DRNN) model. The proposed QDCRNet has achieved a great performance with an accuracy of 90.80 %, sensitivity of 90.50 % and specificity of 90.40 %.</div></div>","PeriodicalId":10616,"journal":{"name":"Computational Biology and Chemistry","volume":"120 ","pages":"Article 108625"},"PeriodicalIF":3.1000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"QDCRNet: Quantum dilated convolutional recurrent network for virus detection using gene expression data\",\"authors\":\"S. Karthi , T. Ramalingam , R. Iyswarya , D. Arul Kumar\",\"doi\":\"10.1016/j.compbiolchem.2025.108625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Viral Infections cause several common human illnesses, like the common cold, flu, mouth blisters, and chickenpox. However, numerous viruses, including rabies, hepatitis, Ebola, avian flu, and coronavirus cause significant health risks due to their high transmission rates. Infections are obligate intracellular parasites that depend on host cellular organisms, resources, and replication for their reproduction and spread. Timely and precise identification of these viruses is vital for appropriate treatment and preventing further spread. However common challenges such as, non-specific symptoms, variability in viral expression, and delayed testing often complicate timely diagnosis. To address this issue, a powerful module named Quantum Dilated Convolutional Recurrent Network (QDCRNet) has been developed for virus detection. Firstly, gene expression data is given into data transformation, and it is done by the Box-Cox transformation. Then, Feature Selection (FS) is performed using Gower distance and mutual information to select the virus-affected region. Finally, detection of the virus is done using QDCRNet, which is the integration of Quantum Dilated Convolutional Neural Network (QDCNN) and Deep Recurrent Neural Network (DRNN) model. The proposed QDCRNet has achieved a great performance with an accuracy of 90.80 %, sensitivity of 90.50 % and specificity of 90.40 %.</div></div>\",\"PeriodicalId\":10616,\"journal\":{\"name\":\"Computational Biology and Chemistry\",\"volume\":\"120 \",\"pages\":\"Article 108625\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computational Biology and Chemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1476927125002865\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computational Biology and Chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1476927125002865","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
QDCRNet: Quantum dilated convolutional recurrent network for virus detection using gene expression data
Viral Infections cause several common human illnesses, like the common cold, flu, mouth blisters, and chickenpox. However, numerous viruses, including rabies, hepatitis, Ebola, avian flu, and coronavirus cause significant health risks due to their high transmission rates. Infections are obligate intracellular parasites that depend on host cellular organisms, resources, and replication for their reproduction and spread. Timely and precise identification of these viruses is vital for appropriate treatment and preventing further spread. However common challenges such as, non-specific symptoms, variability in viral expression, and delayed testing often complicate timely diagnosis. To address this issue, a powerful module named Quantum Dilated Convolutional Recurrent Network (QDCRNet) has been developed for virus detection. Firstly, gene expression data is given into data transformation, and it is done by the Box-Cox transformation. Then, Feature Selection (FS) is performed using Gower distance and mutual information to select the virus-affected region. Finally, detection of the virus is done using QDCRNet, which is the integration of Quantum Dilated Convolutional Neural Network (QDCNN) and Deep Recurrent Neural Network (DRNN) model. The proposed QDCRNet has achieved a great performance with an accuracy of 90.80 %, sensitivity of 90.50 % and specificity of 90.40 %.
期刊介绍:
Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.
Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.
Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.