QDCRNet:利用基因表达数据进行病毒检测的量子扩展卷积循环网络

IF 3.1 4区 生物学 Q2 BIOLOGY
S. Karthi , T. Ramalingam , R. Iyswarya , D. Arul Kumar
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引用次数: 0

摘要

病毒感染会导致几种常见的人类疾病,如普通感冒、流感、口腔水疱和水痘。然而,许多病毒,包括狂犬病、肝炎、埃博拉、禽流感和冠状病毒,由于其高传播率,会造成重大的健康风险。感染是专性细胞内寄生虫,依赖宿主细胞生物、资源和复制进行繁殖和传播。及时和准确地识别这些病毒对于适当治疗和防止进一步传播至关重要。然而,常见的挑战,如非特异性症状、病毒表达的变异性和延迟检测往往使及时诊断复杂化。为了解决这个问题,我们开发了一个强大的用于病毒检测的模块——量子膨胀卷积循环网络(QDCRNet)。首先,将基因表达数据转化为数据,利用Box-Cox变换完成数据转化。然后,利用高尔距离和互信息进行特征选择(FS),选择受病毒影响的区域。最后,利用量子扩展卷积神经网络(QDCNN)和深度递归神经网络(DRNN)模型的集成QDCRNet进行病毒检测。QDCRNet的准确率为90.80 %,灵敏度为90.50 %,特异性为90.40 %。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
QDCRNet: Quantum dilated convolutional recurrent network for virus detection using gene expression data
Viral Infections cause several common human illnesses, like the common cold, flu, mouth blisters, and chickenpox. However, numerous viruses, including rabies, hepatitis, Ebola, avian flu, and coronavirus cause significant health risks due to their high transmission rates. Infections are obligate intracellular parasites that depend on host cellular organisms, resources, and replication for their reproduction and spread. Timely and precise identification of these viruses is vital for appropriate treatment and preventing further spread. However common challenges such as, non-specific symptoms, variability in viral expression, and delayed testing often complicate timely diagnosis. To address this issue, a powerful module named Quantum Dilated Convolutional Recurrent Network (QDCRNet) has been developed for virus detection. Firstly, gene expression data is given into data transformation, and it is done by the Box-Cox transformation. Then, Feature Selection (FS) is performed using Gower distance and mutual information to select the virus-affected region. Finally, detection of the virus is done using QDCRNet, which is the integration of Quantum Dilated Convolutional Neural Network (QDCNN) and Deep Recurrent Neural Network (DRNN) model. The proposed QDCRNet has achieved a great performance with an accuracy of 90.80 %, sensitivity of 90.50 % and specificity of 90.40 %.
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来源期刊
Computational Biology and Chemistry
Computational Biology and Chemistry 生物-计算机:跨学科应用
CiteScore
6.10
自引率
3.20%
发文量
142
审稿时长
24 days
期刊介绍: Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered. Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered. Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.
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