P-wave dispersion in patients with premature ejaculation.

Background: Premature ejaculation (PE) is one of the common male sexual disorders and is associated with autonomic nervous system imbalance. P-wave dispersion (PWD), a marker of atrial electrical heterogeneity and a predictor of atrial arrhythmias, has not been previously investigated in the PE population. This study aimed to investigate PWD in patients with PE and to evaluate whether the subtypes of PE, namely acquired (APE) and lifelong (LLPE), differ in terms of atrial conduction parameters.

Methods: Seventy-eight male patients were included in the study. The distribution of patients was 40 healthy controls, 21 patients with APE, and 17 patients with LLPE. All patients underwent 12-lead electrocardiography to evaluate PWD. Echocardiographic, hormonal, and biochemical parameters were recorded to exclude confounding factors. PWD was defined as the difference between the maximum (Pmax) and minimum P-wave durations (Pmin).

Results: PWD was significantly increased in both PE groups compared to the control group (APE: 44.4 ± 4.1 ms; LLPE: 48.1 ± 2.1 ms; control: 38.2 ± 3.4 ms; p<0.001). Pmin was significantly lower in the PE groups, while Pmax remained comparable among all groups. There was no significant difference in PWD between the PE groups (p=0.38). All patients had normal echocardiographic and hormonal parameters, and there were no significant differences in age, body mass index, blood pressure, or heart rate between the groups.

Conclusions: PWD was significantly higher in patients with PE. This indicates that patients with PE are at a higher risk of developing cardiovascular diseases like atrial fibrillation.