{"title":"埃塞俄比亚中部公立医院15岁以下儿童糖尿病酮症酸中毒的发病率及预测因素：回顾性队列研究","authors":"Sisay Foga Sebro, Sentayehu Admasu Saliya, Taye Mezgebu Ashine, Asnakech Zekiwos Heliso, Habtamu Demisse Dodo, Kinfemicheal Melaku Gebre, Micheal Geletu Alaro, Seifu Awgchew Mamo, Bethelhem Biranu Muluneh, Temesgen Kechine Tibore, Getachew Ossabo Babore, Elias Nigusu Abdisa","doi":"10.1177/11795565251349122","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diabetic ketoacidosis (DKA) is the most serious acute complication of type 1 diabetes mellitus. pediatrics with an incidence rate of 1% to 10% per patient, children have the possibility of dying due to cerebral edema and have significant mortality and morbidity. Diabetic ketoacidosis is unfortunately becoming more common in African nations due to insufficient public healthcare systems.</p><p><strong>Objective: </strong>The objective is to assess the Incidence and Predictors of Diabetic Keto-acidosis Among Children Under 15 Years At Central Ethiopia Public Hospital in A Retrospective Cohort Study 2022.</p><p><strong>Methods: </strong>Wachemo University Specialized Hospital in Hadiya Zone, central Ethiopia, recruited 390 children with diabetes mellitus.</p><p><strong>Design: </strong>It is a retrospective cohort study. The time frame for the study was January 1, 2018, through December 30, 2021. Predictors of diabetic ketoacidosis were examined using the Cox proportional hazard model. In the end, the Cox-regression hazard model contained predictors whose hazard ratio, 95% confidence interval (CI), and <i>P</i>-value were less than .25 in the bivariable analysis. Statistically significant at a <i>P</i>-value of less than .05.</p><p><strong>Result: </strong>A total of 378 child records were examined, yielding a 96.92% response rate. 207 (54.8%) of the 378 recruited children experienced DKA, with a mean follow-up period of 20.83 months and a 95% CI = (49.72, 59.80; 19.54, 22.12). In the cohort, there were 26 incidences of DKA for every 1000 children per month. The following factors were reported to be substantially linked with diabetic ketoacidosis: age <5 years AHR = 2.5 (1.61-3.86), living in a rural location AHR = 1.48 (1.02-2.16), co-morbidity AHR = 1.51 (1.10-2.08), and missed DM follow-up AHR = 1.6 (1.17-2.18).</p><p><strong>Conclusion: </strong>In this study, the incidence of diabetic ketoacidosis was seen in over half of the children. Intervention strategies and early patient identification at risk for this increased incidence of diabetic ketoacidosis.</p>","PeriodicalId":45027,"journal":{"name":"Clinical Medicine Insights-Pediatrics","volume":"19 ","pages":"11795565251349122"},"PeriodicalIF":1.2000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354998/pdf/","citationCount":"0","resultStr":"{\"title\":\"Incidence and Predictors of Diabetic Keto-acidosis Among Children Under 15 Years At Central Ethiopia Public Hospital A Retrospective Cohort Study.\",\"authors\":\"Sisay Foga Sebro, Sentayehu Admasu Saliya, Taye Mezgebu Ashine, Asnakech Zekiwos Heliso, Habtamu Demisse Dodo, Kinfemicheal Melaku Gebre, Micheal Geletu Alaro, Seifu Awgchew Mamo, Bethelhem Biranu Muluneh, Temesgen Kechine Tibore, Getachew Ossabo Babore, Elias Nigusu Abdisa\",\"doi\":\"10.1177/11795565251349122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Diabetic ketoacidosis (DKA) is the most serious acute complication of type 1 diabetes mellitus. pediatrics with an incidence rate of 1% to 10% per patient, children have the possibility of dying due to cerebral edema and have significant mortality and morbidity. Diabetic ketoacidosis is unfortunately becoming more common in African nations due to insufficient public healthcare systems.</p><p><strong>Objective: </strong>The objective is to assess the Incidence and Predictors of Diabetic Keto-acidosis Among Children Under 15 Years At Central Ethiopia Public Hospital in A Retrospective Cohort Study 2022.</p><p><strong>Methods: </strong>Wachemo University Specialized Hospital in Hadiya Zone, central Ethiopia, recruited 390 children with diabetes mellitus.</p><p><strong>Design: </strong>It is a retrospective cohort study. The time frame for the study was January 1, 2018, through December 30, 2021. Predictors of diabetic ketoacidosis were examined using the Cox proportional hazard model. In the end, the Cox-regression hazard model contained predictors whose hazard ratio, 95% confidence interval (CI), and <i>P</i>-value were less than .25 in the bivariable analysis. Statistically significant at a <i>P</i>-value of less than .05.</p><p><strong>Result: </strong>A total of 378 child records were examined, yielding a 96.92% response rate. 207 (54.8%) of the 378 recruited children experienced DKA, with a mean follow-up period of 20.83 months and a 95% CI = (49.72, 59.80; 19.54, 22.12). In the cohort, there were 26 incidences of DKA for every 1000 children per month. The following factors were reported to be substantially linked with diabetic ketoacidosis: age <5 years AHR = 2.5 (1.61-3.86), living in a rural location AHR = 1.48 (1.02-2.16), co-morbidity AHR = 1.51 (1.10-2.08), and missed DM follow-up AHR = 1.6 (1.17-2.18).</p><p><strong>Conclusion: </strong>In this study, the incidence of diabetic ketoacidosis was seen in over half of the children. 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引用次数: 0
摘要
背景：糖尿病酮症酸中毒（DKA）是1型糖尿病最严重的急性并发症。儿科发病率为每例患者1% ~ 10%，患儿有因脑水肿死亡的可能，死亡率和发病率显著。不幸的是，由于公共卫生系统不足，糖尿病酮症酸中毒在非洲国家变得越来越普遍。目的：通过一项回顾性队列研究，评估埃塞俄比亚中部公立医院15岁以下儿童糖尿病酮症酸中毒的发病率和预测因素。方法：埃塞俄比亚中部Hadiya区Wachemo大学专科医院招募390例糖尿病患儿。设计：回顾性队列研究。该研究的时间框架为2018年1月1日至2021年12月30日。采用Cox比例风险模型检验糖尿病酮症酸中毒的预测因子。最后，cox回归风险模型包含风险比、95%置信区间（CI）和p值小于的预测因子。25在双变量分析。p值小于0.05，具有统计学意义。结果：共检查儿童病历378份，有效率96.92%。378名招募的儿童中有207名（54.8%）经历了DKA，平均随访时间为20.83个月，95% CI =(49.72, 59.80; 19.54, 22.12)。在队列中，每月每1000名儿童中有26例DKA发病率。以下因素被报道与糖尿病酮症酸中毒有实质性的联系：年龄结论：在本研究中，糖尿病酮症酸中毒的发生率超过一半的儿童。干预策略和早期患者识别的风险增加发病率糖尿病酮症酸中毒。
Incidence and Predictors of Diabetic Keto-acidosis Among Children Under 15 Years At Central Ethiopia Public Hospital A Retrospective Cohort Study.
Background: Diabetic ketoacidosis (DKA) is the most serious acute complication of type 1 diabetes mellitus. pediatrics with an incidence rate of 1% to 10% per patient, children have the possibility of dying due to cerebral edema and have significant mortality and morbidity. Diabetic ketoacidosis is unfortunately becoming more common in African nations due to insufficient public healthcare systems.
Objective: The objective is to assess the Incidence and Predictors of Diabetic Keto-acidosis Among Children Under 15 Years At Central Ethiopia Public Hospital in A Retrospective Cohort Study 2022.
Methods: Wachemo University Specialized Hospital in Hadiya Zone, central Ethiopia, recruited 390 children with diabetes mellitus.
Design: It is a retrospective cohort study. The time frame for the study was January 1, 2018, through December 30, 2021. Predictors of diabetic ketoacidosis were examined using the Cox proportional hazard model. In the end, the Cox-regression hazard model contained predictors whose hazard ratio, 95% confidence interval (CI), and P-value were less than .25 in the bivariable analysis. Statistically significant at a P-value of less than .05.
Result: A total of 378 child records were examined, yielding a 96.92% response rate. 207 (54.8%) of the 378 recruited children experienced DKA, with a mean follow-up period of 20.83 months and a 95% CI = (49.72, 59.80; 19.54, 22.12). In the cohort, there were 26 incidences of DKA for every 1000 children per month. The following factors were reported to be substantially linked with diabetic ketoacidosis: age <5 years AHR = 2.5 (1.61-3.86), living in a rural location AHR = 1.48 (1.02-2.16), co-morbidity AHR = 1.51 (1.10-2.08), and missed DM follow-up AHR = 1.6 (1.17-2.18).
Conclusion: In this study, the incidence of diabetic ketoacidosis was seen in over half of the children. Intervention strategies and early patient identification at risk for this increased incidence of diabetic ketoacidosis.
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