Baochun Luo, Sifan Liu, Lei Zheng, Baiwen Zhang, Wei Zou
{"title":"膳食铜镁摄入量、老年营养风险指数和全身炎症反应指数与老年人卒中风险的关系","authors":"Baochun Luo, Sifan Liu, Lei Zheng, Baiwen Zhang, Wei Zou","doi":"10.4274/balkanmedj.galenos.2025.2025-7-25","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.</p><p><strong>Aims: </strong>To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.</p><p><strong>Results: </strong>Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.</p><p><strong>Conclusion: </strong>Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"452-463"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402967/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Associations of Dietary Copper and Magnesium Intake, Geriatric Nutritional Risk Index, and Systemic Inflammation Response Index with Stroke Risk in the Elderly\",\"authors\":\"Baochun Luo, Sifan Liu, Lei Zheng, Baiwen Zhang, Wei Zou\",\"doi\":\"10.4274/balkanmedj.galenos.2025.2025-7-25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.</p><p><strong>Aims: </strong>To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.</p><p><strong>Results: </strong>Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.</p><p><strong>Conclusion: </strong>Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.</p>\",\"PeriodicalId\":8690,\"journal\":{\"name\":\"Balkan Medical Journal\",\"volume\":\" \",\"pages\":\"452-463\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402967/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Balkan Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-7-25\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Balkan Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4274/balkanmedj.galenos.2025.2025-7-25","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
The Associations of Dietary Copper and Magnesium Intake, Geriatric Nutritional Risk Index, and Systemic Inflammation Response Index with Stroke Risk in the Elderly
Background: The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.
Aims: To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.
Study design: Cross-sectional study.
Methods: Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.
Results: Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.
Conclusion: Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.
期刊介绍：
The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English.
The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based.
The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
