{"title":"在COVID-19大流行之前和期间丹麦急诊科肺栓塞患者的死亡率：一项多中心回顾性队列研究","authors":"K W Hansen, H Kierkegaard, S V Leth, M Lisby","doi":"10.1111/aas.70099","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In Central Denmark Region, early management of COVID-19 patients was delegated to emergency departments. This study aims to evaluate the mortality of patients admitted with pulmonary embolism, before and during the pandemic, as symptoms could mimic COVID-19.</p><p><strong>Methods: </strong>In this multicenter retrospective cohort study, we included all patients with the action diagnosis of pulmonary embolism admitted to emergency departments in Central Denmark Region between March 1, 2019, and February 28, 2021. The inclusion period defined two equivalent periods before (pre-COVID) and during the COVID-19 pandemic (COVID). The COVID period was used as exposure. 30-day mortality was the primary outcome, while 7-day mortality and transfer to intensive care units were two of the secondary outcomes.</p><p><strong>Results: </strong>A total of 328 and 300 patients with pulmonary embolism were admitted to an emergency department in Central Denmark Region pre and during COVID, respectively. There were no significant associations between admission during COVID and death within 30 days from admission date compared to pre-COVID patients (OR 1.63, 95% CI: 0.88-3.05). Comparing COVID to pre-COVID there were no significant differences in severity upon arrival to hospital (simplified pulmonary Embolism Severity Index 0 or ≥ 1 point(s), p = 0.759) or number of patients transferred to intensive care unit (6 vs. 9, p = 0.340).</p><p><strong>Conclusion: </strong>We found no differences in mortality or in transfer to ICU for patients with pulmonary embolism admitted in Central Denmark Region before or during the COVID-19 pandemic. This study addressed hospital resource management adjustments during the COVID-19 pandemic, and how cases with emergency admission diagnosis of pulmonary embolism fared during the pandemic period compared to other periods outside of the pandemic. For this Danish cohort analysis, pandemic conditions were not associated with different outcomes or ICU access compared to comparison periods.</p>","PeriodicalId":6909,"journal":{"name":"Acta Anaesthesiologica Scandinavica","volume":"69 8","pages":"e70099"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mortality in Patients With Pulmonary Embolism in Danish Emergency Departments Before and During the COVID-19 Pandemic: A Multicenter Retrospective Cohort Study.\",\"authors\":\"K W Hansen, H Kierkegaard, S V Leth, M Lisby\",\"doi\":\"10.1111/aas.70099\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In Central Denmark Region, early management of COVID-19 patients was delegated to emergency departments. This study aims to evaluate the mortality of patients admitted with pulmonary embolism, before and during the pandemic, as symptoms could mimic COVID-19.</p><p><strong>Methods: </strong>In this multicenter retrospective cohort study, we included all patients with the action diagnosis of pulmonary embolism admitted to emergency departments in Central Denmark Region between March 1, 2019, and February 28, 2021. The inclusion period defined two equivalent periods before (pre-COVID) and during the COVID-19 pandemic (COVID). The COVID period was used as exposure. 30-day mortality was the primary outcome, while 7-day mortality and transfer to intensive care units were two of the secondary outcomes.</p><p><strong>Results: </strong>A total of 328 and 300 patients with pulmonary embolism were admitted to an emergency department in Central Denmark Region pre and during COVID, respectively. There were no significant associations between admission during COVID and death within 30 days from admission date compared to pre-COVID patients (OR 1.63, 95% CI: 0.88-3.05). Comparing COVID to pre-COVID there were no significant differences in severity upon arrival to hospital (simplified pulmonary Embolism Severity Index 0 or ≥ 1 point(s), p = 0.759) or number of patients transferred to intensive care unit (6 vs. 9, p = 0.340).</p><p><strong>Conclusion: </strong>We found no differences in mortality or in transfer to ICU for patients with pulmonary embolism admitted in Central Denmark Region before or during the COVID-19 pandemic. This study addressed hospital resource management adjustments during the COVID-19 pandemic, and how cases with emergency admission diagnosis of pulmonary embolism fared during the pandemic period compared to other periods outside of the pandemic. For this Danish cohort analysis, pandemic conditions were not associated with different outcomes or ICU access compared to comparison periods.</p>\",\"PeriodicalId\":6909,\"journal\":{\"name\":\"Acta Anaesthesiologica Scandinavica\",\"volume\":\"69 8\",\"pages\":\"e70099\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Anaesthesiologica Scandinavica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/aas.70099\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Anaesthesiologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/aas.70099","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
Mortality in Patients With Pulmonary Embolism in Danish Emergency Departments Before and During the COVID-19 Pandemic: A Multicenter Retrospective Cohort Study.
Background: In Central Denmark Region, early management of COVID-19 patients was delegated to emergency departments. This study aims to evaluate the mortality of patients admitted with pulmonary embolism, before and during the pandemic, as symptoms could mimic COVID-19.
Methods: In this multicenter retrospective cohort study, we included all patients with the action diagnosis of pulmonary embolism admitted to emergency departments in Central Denmark Region between March 1, 2019, and February 28, 2021. The inclusion period defined two equivalent periods before (pre-COVID) and during the COVID-19 pandemic (COVID). The COVID period was used as exposure. 30-day mortality was the primary outcome, while 7-day mortality and transfer to intensive care units were two of the secondary outcomes.
Results: A total of 328 and 300 patients with pulmonary embolism were admitted to an emergency department in Central Denmark Region pre and during COVID, respectively. There were no significant associations between admission during COVID and death within 30 days from admission date compared to pre-COVID patients (OR 1.63, 95% CI: 0.88-3.05). Comparing COVID to pre-COVID there were no significant differences in severity upon arrival to hospital (simplified pulmonary Embolism Severity Index 0 or ≥ 1 point(s), p = 0.759) or number of patients transferred to intensive care unit (6 vs. 9, p = 0.340).
Conclusion: We found no differences in mortality or in transfer to ICU for patients with pulmonary embolism admitted in Central Denmark Region before or during the COVID-19 pandemic. This study addressed hospital resource management adjustments during the COVID-19 pandemic, and how cases with emergency admission diagnosis of pulmonary embolism fared during the pandemic period compared to other periods outside of the pandemic. For this Danish cohort analysis, pandemic conditions were not associated with different outcomes or ICU access compared to comparison periods.
期刊介绍：
Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.
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