Synthesis of (1,2,4-Triazinyl)furazans

4-Methyl- and 4-amino-1,2,5-oxadiazole-3-carbohydrazonamides reacted with glyoxal to give the corresponding dimeric products, N′,N″-(ethane-1,2-diylidene)bis(4-R-1,2,5-oxadiazole-3-carbohydrazonamides) (R = Me, NH₂), whereas the reaction of the same substrates with other 1,2-dicarbonyl compounds, such as benzil and ninhydrin afforded target 3-(4-R-1,2,5-oxadiazol-3-yl)-1,2,4-triazine derivatives. The product structure was confirmed by IR and NMR spectra and X-ray analysis. The synthesized compounds are promising as scaffolds for the design of pharmacologically active compounds with different kinds of activity.