新的手性双环吡咯烷阻断剂用于Nirmatrelvir及其类似物

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-08-18 DOI:10.1134/S1070428025602833

G. R. Sunagatullina, G. A. Shavaleeva, Z. R. Valiullina, M. S. Miftakhov

引用次数: 0

摘要

（1R,5S）-2-乙氧基-6,6-二甲基-3- azabicycloo[3.1.0]己二烯很容易从(+)-3-蒈烯中获得，被认为是合成Nirmatrelvir及其相关化合物的关键组成部分。它是由(1R,5S)-6,6-二甲基-3-氮杂环[3.1.0]己烷-2- 1与四氟硼酸三乙基氧鎓烯醇化而得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New Chiral Bicyclic Pyrrolidine Block for Nirmatrelvir and Its Analogues

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New Chiral Bicyclic Pyrrolidine Block for Nirmatrelvir and Its Analogues

(1R,5S)-2-Ethoxy-6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-ene easily available from (+)-3-carene has been proposed as a key building block for the synthesis of Nirmatrelvir and related compounds. It has been obtained by enol ethylation of (1R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-one with triethyloxonium tetrafluoroborate.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.