间歇性θ波爆发刺激对脑卒中患者下肢运动功能的影响：系统回顾和荟萃分析

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-08-15 DOI:10.1016/j.clineuro.2025.109112

Hui Zhao, Yue Zhou, Yu Long, Qiongge Yu, Yuyan Liu, Yuhang Wen, Dan Sun, Qiufeng Jia, Yufeng Yu

{"title":"间歇性θ波爆发刺激对脑卒中患者下肢运动功能的影响：系统回顾和荟萃分析","authors":"Hui Zhao, Yue Zhou, Yu Long, Qiongge Yu, Yuyan Liu, Yuhang Wen, Dan Sun, Qiufeng Jia, Yufeng Yu","doi":"10.1016/j.clineuro.2025.109112","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective:</h3><div>To systematically evaluate the effects of intermittent theta burst stimulation(iTBS) on lower limb motor function in stroke patients.</div></div><div><h3>Methods</h3><div>Following the PRISMA guidelines, we searched PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang, and SinoMed from their inception to 23 November 2024. Two researchers independently screened the literature, assessed quality, and extracted data. Statistical analysis was performed using RevMan5.4 and Stata16.0 software.</div></div><div><h3>Results:</h3><div>Thirteen studies involving 516 stroke patients were included. Meta-analysis showed that, compared with the control group, the iTBS group significantly improved lower limb motor function(FMA-LE) scores in stroke patients [MD= 2.31, 95 %CI= (0.78,3.84), <em>P</em> <em><</em> 0.01], as well as lower limb balance function(BBS) [MD= 3.75, 95 %CI= (2.19,5.32), <em>P</em> <em><</em> 0.01]. Subgroup analysis suggested that LE M1-iTBS intervention did not significantly improve FMA-LE scores and balance function. iTBS intervention improved patients' activities of daily living [SMD= 0.67, 95 %CI= (0.46,0.88), <em>P</em> <em><</em> 0.01], and shortened central motor conduction time(CMCT) [SMD= -0.78, 95 %CI= (-1.10, −0.46), <em>P</em> <em><</em> 0.01], but did not show significant improvement in MEP latency (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Existing research evidence indicates that iTBS is an effective treatment method for improving lower limb function in stroke patients, helping to enhance lower limb motor function, lower limb balance, and activities of daily living.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"257 ","pages":"Article 109112"},"PeriodicalIF":1.6000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of intermittent theta burst stimulation on lower limb motor function in stroke patients: A systematic review and meta-analysis\",\"authors\":\"Hui Zhao, Yue Zhou, Yu Long, Qiongge Yu, Yuyan Liu, Yuhang Wen, Dan Sun, Qiufeng Jia, Yufeng Yu\",\"doi\":\"10.1016/j.clineuro.2025.109112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective:</h3><div>To systematically evaluate the effects of intermittent theta burst stimulation(iTBS) on lower limb motor function in stroke patients.</div></div><div><h3>Methods</h3><div>Following the PRISMA guidelines, we searched PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang, and SinoMed from their inception to 23 November 2024. Two researchers independently screened the literature, assessed quality, and extracted data. Statistical analysis was performed using RevMan5.4 and Stata16.0 software.</div></div><div><h3>Results:</h3><div>Thirteen studies involving 516 stroke patients were included. Meta-analysis showed that, compared with the control group, the iTBS group significantly improved lower limb motor function(FMA-LE) scores in stroke patients [MD= 2.31, 95 %CI= (0.78,3.84), <em>P</em> <em><</em> 0.01], as well as lower limb balance function(BBS) [MD= 3.75, 95 %CI= (2.19,5.32), <em>P</em> <em><</em> 0.01]. Subgroup analysis suggested that LE M1-iTBS intervention did not significantly improve FMA-LE scores and balance function. iTBS intervention improved patients' activities of daily living [SMD= 0.67, 95 %CI= (0.46,0.88), <em>P</em> <em><</em> 0.01], and shortened central motor conduction time(CMCT) [SMD= -0.78, 95 %CI= (-1.10, −0.46), <em>P</em> <em><</em> 0.01], but did not show significant improvement in MEP latency (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Existing research evidence indicates that iTBS is an effective treatment method for improving lower limb function in stroke patients, helping to enhance lower limb motor function, lower limb balance, and activities of daily living.</div></div>\",\"PeriodicalId\":10385,\"journal\":{\"name\":\"Clinical Neurology and Neurosurgery\",\"volume\":\"257 \",\"pages\":\"Article 109112\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurology and Neurosurgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0303846725003956\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurology and Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0303846725003956","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：系统评价间歇性θ波爆发刺激（iTBS）对脑卒中患者下肢运动功能的影响。方法按照PRISMA指南，检索PubMed、Web of Science、Embase、Cochrane Library、CNKI、VIP、万方、SinoMed自成立至2024年11月23日的文献。两名研究人员独立筛选文献，评估质量并提取数据。采用RevMan5.4和Stata16.0软件进行统计分析。结果：纳入13项研究，涉及516例脑卒中患者。荟萃分析显示,与对照组相比,招标组显著提高下肢运动功能(FMA-LE)分数在中风患者(MD = 2.31,95 % CI = (0.78,3.84),P & lt; 0.01],以及下肢平衡函数(BBS) (MD = 3.75,95 % CI = (2.19,5.32),P & lt; 0.01]。亚组分析显示，LE M1-iTBS干预未显著改善FMA-LE评分和平衡功能。国际旅游展的干预改善患者的日常生活活动(SMD = 0.67,95 % CI = (0.46,0.88),P & lt; 0.01),并缩短运动中枢传导时间(CMCT) (SMD = -0.78,95 % CI = (-1.10−0.46),P & lt; 0.01],但没有显示显著改善议员延迟(P 祝辞 0.05)。结论现有研究证据表明，iTBS是改善脑卒中患者下肢功能的有效治疗方法，有助于增强下肢运动功能、下肢平衡和日常生活活动能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of intermittent theta burst stimulation on lower limb motor function in stroke patients: A systematic review and meta-analysis

Objective:

To systematically evaluate the effects of intermittent theta burst stimulation(iTBS) on lower limb motor function in stroke patients.

Methods

Following the PRISMA guidelines, we searched PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang, and SinoMed from their inception to 23 November 2024. Two researchers independently screened the literature, assessed quality, and extracted data. Statistical analysis was performed using RevMan5.4 and Stata16.0 software.

Results:

Thirteen studies involving 516 stroke patients were included. Meta-analysis showed that, compared with the control group, the iTBS group significantly improved lower limb motor function(FMA-LE) scores in stroke patients [MD= 2.31, 95 %CI= (0.78,3.84), P < 0.01], as well as lower limb balance function(BBS) [MD= 3.75, 95 %CI= (2.19,5.32), P < 0.01]. Subgroup analysis suggested that LE M1-iTBS intervention did not significantly improve FMA-LE scores and balance function. iTBS intervention improved patients' activities of daily living [SMD= 0.67, 95 %CI= (0.46,0.88), P < 0.01], and shortened central motor conduction time(CMCT) [SMD= -0.78, 95 %CI= (-1.10, −0.46), P < 0.01], but did not show significant improvement in MEP latency (P > 0.05).

Conclusion

Existing research evidence indicates that iTBS is an effective treatment method for improving lower limb function in stroke patients, helping to enhance lower limb motor function, lower limb balance, and activities of daily living.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.