（±）-农单内酯：通过抑制JAK1/STAT3通路有效合成和治疗炎症性肠病

IF 3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2025-08-13 DOI:10.1016/j.bmc.2025.118351

Xiao Zhang , Mingqian Ju , Nanting Zou , Tao Liang , Xiaohong Li , Chunping Wan , Zewei Mao

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引用次数: 0

摘要

炎症性肠病（IBD）是一种慢性反复发作的肠道疾病。在这里，我们开发了一种高效的全合成（±）-agrimonolide，一种从传统药物Agrimonia pilosa Ledeb中提取的化合物。，并在dss诱导的溃疡性结肠炎（UC）小鼠模型中评估其抗炎作用。（±）-农单内酯治疗可显著改善结肠炎症，这可以通过减少粘膜损伤、减少炎症细胞浸润和抑制结肠组织中JAK1/STAT3通路的激活来证明。这些发现强烈提示（±）-农单内酯可能作为治疗IBD的潜在治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

(±)-Agrimonolide: Efficient synthesis and treatment of inflammatory bowel disease via JAK1/STAT3 pathway inhibition

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(±)-Agrimonolide: Efficient synthesis and treatment of inflammatory bowel disease via JAK1/STAT3 pathway inhibition

Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal disorder. Here, we developed an efficient total synthesis of (±)-agrimonolide, a compound derived from the traditional medicine Agrimonia pilosa Ledeb., and evaluated its anti-inflammatory effects in a DSS-induced ulcerative colitis (UC) mouse model. Treatment with (±)-agrimonolide significantly ameliorated colonic inflammation, as evidenced by reducing mucosal damage, decreasing inflammatory cell infiltration, and suppressing the JAK1/STAT3 pathway activation in colonic tissues. These findings strongly suggest that (±)-agrimonolide may serve as a potential therapeutic agent for treating IBD.

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.