{"title":"BMP信号通过控制2组先天淋巴样细胞稳态减轻过敏性气道炎症","authors":"Shan Yue, Huihui Li, Zhiqiang Yan, Mengying Xie, Mengyuan Dai, Mingying Zhang, Wei Xu","doi":"10.1002/eji.70038","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 innate lymphoid cells (ILC2s) in the bone marrow. However, the precise function of BMP signaling in the development and activity of ILC2s remains unclear. This study aimed to investigate whether BMP signaling regulates the generation of ILC2s and their effector functions during lung airway inflammation. We generated BMP receptor 2 (BMPR2) conditional knockout (CKO) mice to analyze ILC2 development and function. We found that BMPR2 deficiency led to an increased number of ILC2s in the lung at steady state, primarily due to enhanced cell proliferation. This expansion resulted in aggravation of early type 2 response in a papain-induced allergic airway inflammation model. BMP4 restrained the proliferation of ILC2s in vitro and in vivo through activation of the canonical BMP signaling pathway. Administration of BMP4 alleviated papain-induced airway inflammation in control mice, whereas this therapeutic effect was abolished in BMPR2 conditional knockout mice. In conclusion, our study demonstrated that BMP signaling regulates allergic airway inflammation by controlling ILC2s homeostasis.</p>\n </div>","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 8","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis\",\"authors\":\"Shan Yue, Huihui Li, Zhiqiang Yan, Mengying Xie, Mengyuan Dai, Mingying Zhang, Wei Xu\",\"doi\":\"10.1002/eji.70038\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 innate lymphoid cells (ILC2s) in the bone marrow. However, the precise function of BMP signaling in the development and activity of ILC2s remains unclear. This study aimed to investigate whether BMP signaling regulates the generation of ILC2s and their effector functions during lung airway inflammation. We generated BMP receptor 2 (BMPR2) conditional knockout (CKO) mice to analyze ILC2 development and function. We found that BMPR2 deficiency led to an increased number of ILC2s in the lung at steady state, primarily due to enhanced cell proliferation. This expansion resulted in aggravation of early type 2 response in a papain-induced allergic airway inflammation model. BMP4 restrained the proliferation of ILC2s in vitro and in vivo through activation of the canonical BMP signaling pathway. Administration of BMP4 alleviated papain-induced airway inflammation in control mice, whereas this therapeutic effect was abolished in BMPR2 conditional knockout mice. In conclusion, our study demonstrated that BMP signaling regulates allergic airway inflammation by controlling ILC2s homeostasis.</p>\\n </div>\",\"PeriodicalId\":165,\"journal\":{\"name\":\"European Journal of Immunology\",\"volume\":\"55 8\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-08-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/eji.70038\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Immunology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/eji.70038","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis
Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 innate lymphoid cells (ILC2s) in the bone marrow. However, the precise function of BMP signaling in the development and activity of ILC2s remains unclear. This study aimed to investigate whether BMP signaling regulates the generation of ILC2s and their effector functions during lung airway inflammation. We generated BMP receptor 2 (BMPR2) conditional knockout (CKO) mice to analyze ILC2 development and function. We found that BMPR2 deficiency led to an increased number of ILC2s in the lung at steady state, primarily due to enhanced cell proliferation. This expansion resulted in aggravation of early type 2 response in a papain-induced allergic airway inflammation model. BMP4 restrained the proliferation of ILC2s in vitro and in vivo through activation of the canonical BMP signaling pathway. Administration of BMP4 alleviated papain-induced airway inflammation in control mice, whereas this therapeutic effect was abolished in BMPR2 conditional knockout mice. In conclusion, our study demonstrated that BMP signaling regulates allergic airway inflammation by controlling ILC2s homeostasis.
期刊介绍:
The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.