使用倾向评分匹配的抗精神病药物治疗精神分裂症患者精神症状网络分析:来自亚洲精神药物处方模式(REAP)研究的结果

IF 3.4 3区 医学 Q2 PSYCHIATRY
Wen Li, Qinge Zhang, Gabor S. Ungvari, Seon-Cheol Park, Lian-Yu Chen, Kok Yoon Chee, Roy Abraham Kallivayalil, Kang Sim, Yan-Ling He, Norman Sartorius, Naotaka Shinfuku, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Takahiro A. Kato, Chee H. Ng, Yu-Tao Xiang
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引用次数: 0

摘要

目的抗精神病药物多药(APP)在亚洲各国精神分裂症患者中普遍存在。本研究旨在通过网络分析探讨精神症状与APP之间的关系。方法从亚洲精神药物处方模式研究(REAP-AP)第四次调查中提取9种主要精神症状和抗精神病药物处方数量的数据。应用APP和单药抗精神病治疗分别建立九种精神症状的网络模型。应用网络分析进一步分析精神症状与APP使用之间的相互关系。结果亚洲地区共1528例应用APP治疗的精神分裂症患者与1528例应用APM治疗的精神分裂症患者相匹配。在精神症状网络中,前三名的中心精神症状是一致的,但app治疗的患者(言语攻击、幻觉、社会/职业功能障碍)和apm治疗的患者(社会/职业功能障碍、言语攻击、幻觉)的顺序不同。APP与精神症状的网络分析显示,紊乱/紧张性行为与APP密切相关,其次是妄想、幻觉和言语攻击。结论与APP密切相关的精神症状包括言语攻击、严重紊乱/紧张性行为、妄想和幻觉。对于主要表现出这些症状的精神分裂症患者,应考虑其他适当的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Network Analysis of Psychiatric Symptoms in Patients With Schizophrenia Treated With Antipsychotic Polypharmacy Using Propensity Score Matching: Findings From the Research on Asian Psychotropic Prescription Patterns (REAP) Study

Objectives

Antipsychotic polypharmacy (APP) is prevalent among patients with schizophrenia across countries in Asia. This study aimed to explore the relationships between psychiatric symptoms and APP using network analysis.

Methods

Data on nine major psychiatric symptoms and the number of prescribed antipsychotics were extracted from the fourth survey of the Research on Asian Psychotropic Prescription Patterns (REAP-AP). A network model of the nine psychiatric symptoms was constructed for patients treated with APP and antipsychotic monotherapy (APM) respectively. The interconnections between psychiatric symptoms and APP use were further analyzed using network analysis.

Results

A total of 1528 patients with schizophrenia treated with APP were matched with 1528 patients treated with APM in Asia. The top three central psychiatric symptoms in the networks of psychiatric symptoms were consistent, but in different orders for APP-treated patients (verbal aggression, hallucinations, and social/occupational dysfunction) and APM-treated patients (social/occupational dysfunction, verbal aggression, and hallucinations). Network analysis of APP and psychiatric symptoms revealed that disorganized/catatonic behavior was strongly linked with APP, followed by delusions, hallucinations, and verbal aggression.

Conclusion

Psychiatric symptoms closely associated with APP included verbal aggression, grossly disorganized/catatonic behavior, delusions, and hallucinations. For patients with schizophrenia who are primarily exhibiting such symptoms, alternative appropriate treatment strategies should be considered.

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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: Asia-Pacific Psychiatry is an international psychiatric journal focused on the Asia and Pacific Rim region, and is the official journal of the Pacific Rim College of Psychiatrics. Asia-Pacific Psychiatry enables psychiatric and other mental health professionals in the region to share their research, education programs and clinical experience with a larger international readership. The journal offers a venue for high quality research for and from the region in the face of minimal international publication availability for authors concerned with the region. This includes findings highlighting the diversity in psychiatric behaviour, treatment and outcome related to social, ethnic, cultural and economic differences of the region. The journal publishes peer-reviewed articles and reviews, as well as clinically and educationally focused papers on regional best practices. Images, videos, a young psychiatrist''s corner, meeting reports, a journal club and contextual commentaries differentiate this journal from existing main stream psychiatry journals that are focused on other regions, or nationally focused within countries of Asia and the Pacific Rim.
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