酒精相关性肝炎门静脉高压症：是无害的还是全身性炎症的反映？

IF 2.4 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-08-13 DOI:10.1016/j.clinre.2025.102668

Karim Gebara , Lionel Moulis , Joana Pissarra , Benjamin Rivière , Georges-Philippe Pageaux , José Ursic-Bedoya

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引用次数: 0

摘要

背景和目的：门静脉高压是酒精相关性肝炎的一个显著特征。然而，目前尚不清楚PH的严重程度是否对AH的预后有影响。我们研究的目的是评估PH对6个月无移植生存（TFS）的影响。方法：对2013年1月至2021年12月在我院三级医院就诊的经组织学证实的有症状AH患者进行单中心回顾性分析。结果：127例患者纳入研究，平均判别函数和MELD评分分别为59.5（±23.5）和25.2（±6.6）。入院时严重PH的唯一危险因素是肝/脾比例。患者随访时间中位数为20个月。中位TFS为16.8个月。与MELD评分和对皮质类固醇无反应不同，严重PH与6个月TFS没有显著相关。此外，白细胞计数与6个月时的持续PH值有关。结论：在我们的研究中，严重PH对6个月的TFS没有影响。进一步研究PH值的预后价值及其在AH中的自然历史是必要的。

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Portal hypertension in alcohol-associated hepatitis: harmless and the reflection of systemic inflammation?

Background and Aims

Portal hypertension is a prominent feature of alcohol-associated hepatitis. However, it is not established whether the severity of PH has a prognostic impact in AH. The aim of our study was to assess the impact of PH on 6-month transplantation-free survival (TFS).

Methods

A monocentric retrospective analysis was conducted on patients with symptomatic AH, proven histologically, admitted in our tertiary care hospital from January 2013 to December 2021.

Results

127 patients were included in the study, with a mean Discriminant Function and MELD score of 59.5 (±23.5) and 25.2 (±6.6), respectively. The only risk factor for severe PH at admission was the liver/spleen ratio. Patients were followed up for a median of 20 months. The median TFS was 16.8 months. Severe PH was not significantly associated with 6-month TFS, unlike the MELD score and nonresponse to corticosteroids. In addition, the leucocyte count was associated with persistent PH at 6 months.

Conclusions

In our study, severe PH had no impact on 6-month TFS. Further investigations on the prognostic value of PH and its natural history in AH are warranted.

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.