COVID-19预防计划:针对拉丁美洲人预防COVID-19家庭和社区传播的量身定制行为干预的基本原理和方法。

IF 1.9 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Noe C. Crespo , Job Godino , Alma Behar , Patricia Dionicio , Carolina Lopez de la Torre , Kiria Fraga , Marco Santoscoy , John P. Elder , Eyal Oren , Chii-Dean Lin , Elva M. Arredondo , Hala Madanat , Christian B. Ramers
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引用次数: 0

摘要

背景:COVID-19对服务不足的社区造成了不成比例的影响,例如生活在美国的拉丁美洲人。Promotoras(社区卫生工作者)可以有效地提供量身定制的和与文化相关的策略,以防止拉丁美洲人和其他少数群体的家庭传播和SARS-CoV-2的负担。目的:制定、实施和测试以诊所为基础的由推广者主导的COVID-19预防计划(CPP),以减少256个拉丁裔家庭和社区中SARS-CoV-2的传播。设计:CPP是一项两组随机对照试验,旨在测试促进者主导的干预的近期、中期和长期有效性,并测试其对短期和长期行为、心理和身体健康结果的有效性。主要结局是在6 周和6、12和24个月时评估家庭感染率,基于通过抗原、实时逆转录聚合酶链反应(RT-PCR)和家庭成员中SARS-CoV-2抗体检测结果评估新感染证据的二元指标(是或否)。干预组的患者将接受强化的标准治疗,包括由推广人员提供量身定制的实时短信和虚拟咨询。对照组患者接受临床标准治疗。分析将测试与已确定的指示病例相关的新感染的家庭水平组差异。讨论:预防SARS-CoV-2的家庭传播是减轻拉丁美洲人SARS-CoV-2总体负担的重要策略。CPP是一种可扩展和量身定制的方法,有可能成为解决未来呼吸道疾病暴发的模式,特别是在无保险、低收入和医疗服务不足的社区。试验注册:Clinicaltrials.gov标识符NCT05697068(1/20/2023)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID Prevention Program: Rationale and methodology of a tailored behavioral intervention to prevent household and community spread of COVID-19 among Latinos

Background

COVID-19 has disproportionately affected underserved communities, such as Latinos living in the U.S. Promotoras (Community Health Workers) may be effective at delivering tailored and culturally relevant strategies to prevent household spread and the burden of SARS-CoV-2 among Latinos and other minority groups.

Purpose

To develop, implement, and test the clinic-based promotora-led COVID-19 Prevention Program (CPP) to reduce transmission of SARS-CoV-2 in 256 Latino households and the community.

Design

CPP is a two-group randomized controlled trial designed to test the immediate, mid-term, and long-term effectiveness of the promotora-led intervention, as well as test its effectiveness on short- and long-term behavioral, mental, and physical health outcomes. The primary outcome is household infection rate assessed at 6 weeks and 6-, 12-, and 24-months based on a binary indicator (yes vs. no) of evidence of a new infection via antigen, real-time reverse transcriptase-polymerase chain reaction (RT-PCR), or antibody SARS-CoV-2 test results within household members. Patients in the intervention group will receive enhanced standard-of-care, including tailored, real-time text messaging and virtual counseling, delivered by promotoras. Patients in the control group will receive the clinical standard of care. Analyses will test for household-level group differences in new infections related to an identified index case.

Discussion

Preventing household spread of SARS-CoV-2 is an important strategy to reduce the overall burden of SARS-CoV-2 among Latinos. The CPP is a scalable and tailored approach that has the potential to serve as a model to address future respiratory disease outbreaks, especially among uninsured, low-income, and medically underserved communities.
Trial registration: Clinicaltrials.gov Identifier NCT05697068 (1/20/2023).
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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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