{"title":"将SWI/SNF复合物用于癌症治疗。","authors":"Hongyan Jing, Xi Zhang, Linghua Meng","doi":"10.1016/j.tips.2025.07.008","DOIUrl":null,"url":null,"abstract":"<p><p>SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies. In this review, we integrate large-scale cancer genomic data towards understanding tumorigenesis driven by alterations in subunits of SWI/SNF complexes. We also evaluate strategies exploiting vulnerabilities in SWI/SNF-mutant cancers, including direct targeting of residual complex components and unique dependencies in critical cellular processes. Among them, one drug has been approved, and several others are in clinical trials.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"907-921"},"PeriodicalIF":19.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Swinging the SWI/SNF complexes for cancer therapy.\",\"authors\":\"Hongyan Jing, Xi Zhang, Linghua Meng\",\"doi\":\"10.1016/j.tips.2025.07.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies. In this review, we integrate large-scale cancer genomic data towards understanding tumorigenesis driven by alterations in subunits of SWI/SNF complexes. We also evaluate strategies exploiting vulnerabilities in SWI/SNF-mutant cancers, including direct targeting of residual complex components and unique dependencies in critical cellular processes. Among them, one drug has been approved, and several others are in clinical trials.</p>\",\"PeriodicalId\":23250,\"journal\":{\"name\":\"Trends in pharmacological sciences\",\"volume\":\" \",\"pages\":\"907-921\"},\"PeriodicalIF\":19.9000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tips.2025.07.008\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tips.2025.07.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Swinging the SWI/SNF complexes for cancer therapy.
SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies. In this review, we integrate large-scale cancer genomic data towards understanding tumorigenesis driven by alterations in subunits of SWI/SNF complexes. We also evaluate strategies exploiting vulnerabilities in SWI/SNF-mutant cancers, including direct targeting of residual complex components and unique dependencies in critical cellular processes. Among them, one drug has been approved, and several others are in clinical trials.
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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