疟蚊阻断疟疾传播共生体孢子发生的发现。

IF 3.1 2区生物学 Q2 MICROBIOLOGY

mSphere Pub Date : 2025-09-30 Epub Date: 2025-08-15 DOI:10.1128/msphere.00325-25

Jeremy K Herren

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引用次数: 0

摘要

在最近的工作中，Parry等人提供了微孢子虫MB孢子形成的详细可视化（E. R. S. Parry， R. Pevsner， B. C. Poulton， D.-K.）。Purusothaman, et ., mSphere 10:e00851- 24,2025, https://doi.org/10.1128/msphere.00851-24)。他们的研究结果表明，MB微孢子虫定位于蚊子种系组织，并在发育中的卵母细胞内发生八孢子体，这表明它有垂直和潜在的水平传播途径。具有标志性微孢子结构的孢子的鉴定加强了通过卵沉积进行环境传播的情况。这些结果填补了关键的生物学知识空白，并为体内共生成像设定了新的方法标准。这项工作提高了微孢子虫MB作为阻断传播共生体的可行性，并支持其作为一种新的、可持续的疟疾控制工具的发展。

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Discovery of sporogeny in the malaria transmission-blocking symbiont of Anopheles mosquitoes.

In recent work, Parry et al. provide a detailed visualization of Microsporidia MB sporogeny (E. R. S. Parry, R. Pevsner, B. C. Poulton, D.-K. Purusothaman, et al., mSphere 10:e00851-24, 2025, https://doi.org/10.1128/msphere.00851-24). Their findings reveal that Microsporidia MB is localized to mosquito germline tissues and undergoes octosporogony within developing oocytes, suggesting both vertical and potential horizontal transmission routes. The identification of spores with hallmark microsporidian structures strengthens the case for environmental dissemination via egg deposition. These results fill key biological knowledge gaps and set new methodological standards for in vivo symbiont imaging. This work advances Microsporidia MB's feasibility as a transmission-blocking symbiont and supports its development as a novel, sustainable malaria control tool.

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来源期刊

mSphere Immunology and Microbiology-Microbiology

CiteScore

8.50

自引率

2.10%

发文量

192

审稿时长

11 weeks

期刊介绍： mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.