破解谜题:长链非编码rna在疾病发病机制和治疗前景。

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Palaniappan Ramesh, Pallavi Muthyala, Suresh Kumar Kali
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引用次数: 0

摘要

尽管在疾病理解和治疗干预方面取得了进展,但全球疾病负担继续迅速增加,强调需要新的见解和方法。长链非编码rna (lncRNAs)在生物过程中发挥着关键作用,影响着基因表达调控和细胞信号通路。这篇综述探讨了lncrna在调节染色质功能、调节核体和影响翻译后修饰中的复杂作用。此外,它们与各种RNA物种和蛋白质的相互作用显著影响细胞信号级联反应,从而导致多种病理生理状况,包括癌症、神经系统疾病、代谢综合征和自身免疫性疾病。我们强调lncrna作为诊断生物标志物和临床治疗靶点的潜力。通过描述lncrna在疾病机制中的复杂参与,本综述旨在促进该领域的进一步研究,鼓励对疾病发病机制的更深入了解,并为创新的治疗策略铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deciphering the enigma: long noncoding RNAs in disease pathogenesis and therapeutic prospects.

Despite advancements in disease understanding and therapeutic interventions, the global burden of diseases continues to increase rapidly, emphasizing the need for novel insights and approaches. Long noncoding RNAs (lncRNAs) have emerged as key players in biological processes and influence gene expression regulation and cellular signalling pathways. This review explores the complex roles of lncRNAs in modulating chromatin function, regulating nuclear bodies, and impacting posttranslational modifications. Moreover, their interactions with various RNA species and proteins significantly influence cell signalling cascades, thereby contributing to diverse pathophysiological conditions, including cancer, neurological disorders, metabolic syndromes, and autoimmune diseases. We highlight the potential of lncRNAs as diagnostic biomarkers and therapeutic targets in clinical settings. By describing the complex involvement of lncRNAs in disease mechanisms, this review aims to stimulate further research in this field, encouraging a deeper understanding of disease pathogenesis and paving the way for innovative therapeutic strategies.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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