用于BNCT的SPECT实时剂量监测系统的研制与仿真:LENA反应堆的响应

IF 2.7 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
L. Santini , T. Ferri , L. Grisoni , A. Caracciolo , D. Bortot , G. Borghi , A. Pola , S. Agosteo , V. Pascali , N. Protti , D.Ramos Lòpez , N. Ferrara , D. Mazzucconi
{"title":"用于BNCT的SPECT实时剂量监测系统的研制与仿真:LENA反应堆的响应","authors":"L. Santini ,&nbsp;T. Ferri ,&nbsp;L. Grisoni ,&nbsp;A. Caracciolo ,&nbsp;D. Bortot ,&nbsp;G. Borghi ,&nbsp;A. Pola ,&nbsp;S. Agosteo ,&nbsp;V. Pascali ,&nbsp;N. Protti ,&nbsp;D.Ramos Lòpez ,&nbsp;N. Ferrara ,&nbsp;D. Mazzucconi","doi":"10.1016/j.ejmp.2025.105070","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Boron Neutron Capture Therapy (BNCT) selectively targets tumor cells while sparing healthy ones, by exploiting neutron capture on boron-10, which accumulates to the cancerous cells. To ensure that the therapy is properly tuned, real-time dose monitoring during treatment plays a fundamental role. A Single Photon Emission Computed Tomography (SPECT) imaging system relying on the 478 keV gamma ray emitted by the neutron capture reaction, can, in principle, detect the boron distribution and allow the 3D reconstruction of the dose inside the patient. However, neutron interactions with all the other elements present in tissues and structures introduce background signals, complicating dose evaluation.</div></div><div><h3>Methods</h3><div>In this study, FLUKA Monte Carlo simulations were applied to a BNCT-SPECT oriented detector to simulate the image reconstruction process. The simulations were conducted by irradiating the system at the LENA (Laboratorio Energia Nucleare Applicata) in Pavia and compared with experimental data. Moreover, a proof-of-concept study on a SPECT acquisition have been performed on different borated samples.</div></div><div><h3>Results</h3><div>The experimental and simulated results are in good agreement for both image acquisition and detected counting rates. The simulated projections, reconstructed with an appropriated iterative algorithm, show that the presented system is capable of distinguishing two separated vials containing boron-10.</div></div><div><h3>Conclusion</h3><div>This study show that the presented system holds a good promise for enhancing the precision of dose monitoring and localization during clinical BNCT treatments. For this reason, the system will be deployed in real BNCT facilities to evaluate and validate its performance under clinical conditions.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105070"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and simulation of a SPECT real time dose monitoring system for BNCT: response at the LENA reactor\",\"authors\":\"L. Santini ,&nbsp;T. Ferri ,&nbsp;L. Grisoni ,&nbsp;A. Caracciolo ,&nbsp;D. Bortot ,&nbsp;G. Borghi ,&nbsp;A. Pola ,&nbsp;S. Agosteo ,&nbsp;V. Pascali ,&nbsp;N. Protti ,&nbsp;D.Ramos Lòpez ,&nbsp;N. Ferrara ,&nbsp;D. Mazzucconi\",\"doi\":\"10.1016/j.ejmp.2025.105070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Boron Neutron Capture Therapy (BNCT) selectively targets tumor cells while sparing healthy ones, by exploiting neutron capture on boron-10, which accumulates to the cancerous cells. To ensure that the therapy is properly tuned, real-time dose monitoring during treatment plays a fundamental role. A Single Photon Emission Computed Tomography (SPECT) imaging system relying on the 478 keV gamma ray emitted by the neutron capture reaction, can, in principle, detect the boron distribution and allow the 3D reconstruction of the dose inside the patient. However, neutron interactions with all the other elements present in tissues and structures introduce background signals, complicating dose evaluation.</div></div><div><h3>Methods</h3><div>In this study, FLUKA Monte Carlo simulations were applied to a BNCT-SPECT oriented detector to simulate the image reconstruction process. The simulations were conducted by irradiating the system at the LENA (Laboratorio Energia Nucleare Applicata) in Pavia and compared with experimental data. Moreover, a proof-of-concept study on a SPECT acquisition have been performed on different borated samples.</div></div><div><h3>Results</h3><div>The experimental and simulated results are in good agreement for both image acquisition and detected counting rates. The simulated projections, reconstructed with an appropriated iterative algorithm, show that the presented system is capable of distinguishing two separated vials containing boron-10.</div></div><div><h3>Conclusion</h3><div>This study show that the presented system holds a good promise for enhancing the precision of dose monitoring and localization during clinical BNCT treatments. For this reason, the system will be deployed in real BNCT facilities to evaluate and validate its performance under clinical conditions.</div></div>\",\"PeriodicalId\":56092,\"journal\":{\"name\":\"Physica Medica-European Journal of Medical Physics\",\"volume\":\"137 \",\"pages\":\"Article 105070\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica Medica-European Journal of Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1120179725001802\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179725001802","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

硼中子捕获疗法(BNCT)通过利用硼-10的中子捕获,选择性地靶向肿瘤细胞,同时保留健康细胞。硼-10积聚到癌细胞中。为了确保适当调整治疗,治疗期间的实时剂量监测起着重要作用。单光子发射计算机断层扫描(SPECT)成像系统依靠中子捕获反应发射的478 keV伽马射线,原则上可以检测硼的分布,并允许对患者体内的剂量进行三维重建。然而,中子与组织和结构中存在的所有其他元素的相互作用引入了背景信号,使剂量评估复杂化。方法本研究采用FLUKA蒙特卡罗模拟方法对BNCT-SPECT定向检测器进行图像重建过程模拟。在帕维亚的核能应用实验室(LENA)对该系统进行了模拟,并与实验数据进行了比较。此外,对不同含硼样品进行了SPECT采集的概念验证研究。结果实验结果与仿真结果在图像采集率和检测计数率上基本一致。模拟投影,用适当的迭代算法重建,表明该系统能够区分两个分离的含有硼-10的小瓶。结论该系统可提高临床BNCT治疗中剂量监测和定位的精度。因此,该系统将在实际的BNCT设施中部署,以评估和验证其在临床条件下的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and simulation of a SPECT real time dose monitoring system for BNCT: response at the LENA reactor

Background

Boron Neutron Capture Therapy (BNCT) selectively targets tumor cells while sparing healthy ones, by exploiting neutron capture on boron-10, which accumulates to the cancerous cells. To ensure that the therapy is properly tuned, real-time dose monitoring during treatment plays a fundamental role. A Single Photon Emission Computed Tomography (SPECT) imaging system relying on the 478 keV gamma ray emitted by the neutron capture reaction, can, in principle, detect the boron distribution and allow the 3D reconstruction of the dose inside the patient. However, neutron interactions with all the other elements present in tissues and structures introduce background signals, complicating dose evaluation.

Methods

In this study, FLUKA Monte Carlo simulations were applied to a BNCT-SPECT oriented detector to simulate the image reconstruction process. The simulations were conducted by irradiating the system at the LENA (Laboratorio Energia Nucleare Applicata) in Pavia and compared with experimental data. Moreover, a proof-of-concept study on a SPECT acquisition have been performed on different borated samples.

Results

The experimental and simulated results are in good agreement for both image acquisition and detected counting rates. The simulated projections, reconstructed with an appropriated iterative algorithm, show that the presented system is capable of distinguishing two separated vials containing boron-10.

Conclusion

This study show that the presented system holds a good promise for enhancing the precision of dose monitoring and localization during clinical BNCT treatments. For this reason, the system will be deployed in real BNCT facilities to evaluate and validate its performance under clinical conditions.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信