妊娠后复发的肝内胆汁淤积症。

IF 4.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Obstetrics and gynecology Pub Date : 2025-08-14 DOI:10.1097/aog.0000000000006033

Henri M Rosenberg,Minhazur R Sarker,Gladys A Ramos,Angela Bianco,Lauren Ferrara,Chelsea A DeBolt

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引用次数: 0

摘要

根据先前的文献报道，妊娠期肝内胆汁淤积症（ICP）的复发率从40%到90%不等，但数据仍然有限。在一项回顾性队列研究中，我们旨在评估ICP复发率和与复发相关的危险因素。在104例指数妊娠的ICP患者中，46例（44%）在随后的妊娠中出现ICP复发。指数妊娠总胆汁酸（TBA）峰值大于40微摩尔/L与ICP复发显著相关；较短的解释间隔与较低的风险相关。这些发现为现代不同种族人群中ICP复发风险的文献研究做出了贡献，并强调TBA水平升高是复发的预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Intrahepatic Cholestasis of Pregnancy Recurrence in a Subsequent Pregnancy.

Reported recurrence rates of intrahepatic cholestasis of pregnancy (ICP) range from 40% to 90% based on prior literature, but data remain limited. In a retrospective cohort, we aimed to evaluate the rate of ICP recurrence and risk factors associated with recurrence. Among 104 patients with ICP in an index pregnancy, 46 experienced recurrence (44%) of ICP in subsequent pregnancy. A peak total bile acid (TBA) level greater than 40 micromoles/L in the index pregnancy was significantly associated with ICP recurrence; shorter interpregnancy intervals were associated with lower risk. These findings contribute to the literature on the risk of ICP recurrence in a modern, racially diverse cohort and highlight elevated TBA level as a predictor of recurrence.

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来源期刊

Obstetrics and gynecology 医学-妇产科学

CiteScore

11.10

自引率

4.20%

发文量

867

审稿时长

1 months

期刊介绍： "Obstetrics & Gynecology," affectionately known as "The Green Journal," is the official publication of the American College of Obstetricians and Gynecologists (ACOG). Since its inception in 1953, the journal has been dedicated to advancing the clinical practice of obstetrics and gynecology, as well as related fields. The journal's mission is to promote excellence in these areas by publishing a diverse range of articles that cover translational and clinical topics. "Obstetrics & Gynecology" provides a platform for the dissemination of evidence-based research, clinical guidelines, and expert opinions that are essential for the continuous improvement of women's health care. The journal's content is designed to inform and educate obstetricians, gynecologists, and other healthcare professionals, ensuring that they stay abreast of the latest developments and best practices in their field.