{"title":"低频重复经颅磁刺激联合认知行为疗法对首发抑郁症伴失眠患者神经心理状态、认知功能及睡眠微观结构的影响","authors":"Guo-Rong Shi, Ling-Li Hui","doi":"10.1080/08869634.2025.2544383","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with insomnia.</p><p><strong>Methods: </strong>The clinical data of 95 first-episode depression patients with insomnia were retrospectively analyzed. The patients were divided into groups according to the different therapeutic regimens, 45 cases in the control group received conventional treatment, and 50 cases in the research group received rTMS combined with CBT on the basis of conventional treatment. The clinical efficacy, depression level, cognitive function, neuropsychology and sleep quality of the two groups were compared.</p><p><strong>Results: </strong>The overall efficacy rate was higher in the research group compared to the control group (96.00% vs. 80.00%) (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>In addition to conventional pharmacological treatment, the combination of rTMS and CBT may serve as a promising adjunctive intervention for first-episode depression patients with insomnia, demonstrating potential benefits in improving neuropsychological status, cognitive function, and sleep microstructure.</p>","PeriodicalId":56318,"journal":{"name":"Cranio-The Journal of Craniomandibular & Sleep Practice","volume":" ","pages":"1-11"},"PeriodicalIF":1.9000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of low-frequency repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with comorbid insomnia.\",\"authors\":\"Guo-Rong Shi, Ling-Li Hui\",\"doi\":\"10.1080/08869634.2025.2544383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with insomnia.</p><p><strong>Methods: </strong>The clinical data of 95 first-episode depression patients with insomnia were retrospectively analyzed. The patients were divided into groups according to the different therapeutic regimens, 45 cases in the control group received conventional treatment, and 50 cases in the research group received rTMS combined with CBT on the basis of conventional treatment. The clinical efficacy, depression level, cognitive function, neuropsychology and sleep quality of the two groups were compared.</p><p><strong>Results: </strong>The overall efficacy rate was higher in the research group compared to the control group (96.00% vs. 80.00%) (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>In addition to conventional pharmacological treatment, the combination of rTMS and CBT may serve as a promising adjunctive intervention for first-episode depression patients with insomnia, demonstrating potential benefits in improving neuropsychological status, cognitive function, and sleep microstructure.</p>\",\"PeriodicalId\":56318,\"journal\":{\"name\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08869634.2025.2544383\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cranio-The Journal of Craniomandibular & Sleep Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08869634.2025.2544383","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨低频重复经颅磁刺激（rTMS）联合认知行为疗法（CBT）对首发抑郁症伴失眠患者神经心理状态、认知功能及睡眠微观结构的影响。方法：回顾性分析95例首发抑郁症伴失眠患者的临床资料。根据不同的治疗方案将患者分组，对照组45例接受常规治疗，研究组50例在常规治疗的基础上接受rTMS联合CBT治疗。比较两组患者的临床疗效、抑郁程度、认知功能、神经心理及睡眠质量。结果：研究组的总有效率高于对照组（96.00% vs. 80.00%） (p)。结论：rTMS联合CBT治疗首发抑郁症伴失眠患者，除常规药物治疗外，在改善神经心理状态、认知功能和睡眠微观结构方面具有潜在的益处，是一种有前景的辅助干预方法。
Effects of low-frequency repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with comorbid insomnia.
Objective: To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with insomnia.
Methods: The clinical data of 95 first-episode depression patients with insomnia were retrospectively analyzed. The patients were divided into groups according to the different therapeutic regimens, 45 cases in the control group received conventional treatment, and 50 cases in the research group received rTMS combined with CBT on the basis of conventional treatment. The clinical efficacy, depression level, cognitive function, neuropsychology and sleep quality of the two groups were compared.
Results: The overall efficacy rate was higher in the research group compared to the control group (96.00% vs. 80.00%) (p < .05).
Conclusion: In addition to conventional pharmacological treatment, the combination of rTMS and CBT may serve as a promising adjunctive intervention for first-episode depression patients with insomnia, demonstrating potential benefits in improving neuropsychological status, cognitive function, and sleep microstructure.
期刊介绍：
CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians.
CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest.
CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.
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