多巴胺受体和去甲肾上腺素转运蛋白相关的破坏与COVID-19幸存者的抑郁和认知表现有关

Yao Wang , Ziwei Yang , Xiao Liang , Lin Wu , Chengsi Wu , Jiankun Dai , Yuan Cao , Xianjun Zeng , Meng Li , Fuqing Zhou
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引用次数: 0

摘要

目的探讨新冠肺炎幸存者神经活动、神经血管偶联(NVC)和神经递质受体之间的关系,以及它们与情绪和认知的关系。材料和方法共招募了42名COVID-19幸存者和30名匹配的健康对照(hc)。计算区域均匀性(ReHo)和功能连接强度(FCS),分别评估局部和全局神经活动。脑血流(CBF)表征为脑灌注。在体素水平上使用CBF/ReHo和CBF/FCS比率来评估区域NVC。神经递质受体图谱来源于JuSpace工具箱,该工具箱集成了健康人群的正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)数据。这些地图包括16种受体/转运蛋白,如多巴胺、血清素、去甲肾上腺素和谷氨酸受体等。随后分析了COVID-19幸存者的神经活动、NVC和神经递质受体图谱之间的空间相关性。结果无论是检测神经活动还是NVC,与HC相比,COVID-19幸存者主要表现为ReHo或CBF/ReHo模式降低。此外,在COVID-19幸存者中,神经递质受体分布仅与局部神经活动(如ReHo)和NVC(如CBF/ReHo)有很强的相关性。具体来说,ReHo的空间模式与多巴胺受体、谷氨酸受体和去甲肾上腺素转运蛋白相关,但CBF/ReHo仅与多巴胺受体相关。重要的是,ReHo与多巴胺受体或去甲肾上腺素转运蛋白之间的相关系数与COVID-19幸存者的认知表现相关。相反,CBF/ReHo和多巴胺之间的相关系数与COVID-19幸存者的抑郁相关。结论covid -19幸存者表现出与多巴胺受体和去甲肾上腺素转运体相关的局部神经活动和NVC破坏。这些改变与抑郁和认知障碍有关,提示神经和神经血管功能受损的潜在分子基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dopamine receptor- and noradrenaline transporter-related disruptions are associated with depression and cognitive performance in COVID-19 survivors

Dopamine receptor- and noradrenaline transporter-related disruptions are associated with depression and cognitive performance in COVID-19 survivors

Purpose

This study aims to explore the relationships between neural activity, neurovascular coupling (NVC), and neurotransmitter receptors, and to investigate their association with emotion and cognition in COVID-19 survivors.

Materials and methods

A total of 42 COVID-19 survivors and 30 matched healthy controls (HCs) were recruited. Regional homogeneity (ReHo) and functional connectivity strength (FCS) were calculated -to assess local and global neural activity, respectively. Cerebral blood flow (CBF) was characterized as brain perfusion. Regional NVC was evaluated using CBF/ReHo and CBF/FCS ratios at the voxel level. Neurotransmitter receptor maps were derived from the JuSpace toolbox, which integrates positron emission tomography (PET) and single-photon emission computed tomography (SPECT) data from healthy populations. These maps included 16 receptor/transporters, such as dopamine, serotonin, norepinephrine and glutamate receptors, among others. Spatial correlations between neural activity, NVC and neurotransmitter receptor maps were subsequently analyzed in COVID-19 survivors.

Results

Whether examining neural activity or NVC, COVID-19 survivors primariily exhibiteddecreased ReHo or CBF/ReHo pattern compared to HC. Moreover, the neurotransmitter receptor distributions showed strong associations exclusively with local neural activity (e.g., ReHo) and NVC (e.g., CBF/ReHo) in COVID-19 survivors. Specifically, the spatial pattern of ReHo correlated with dopamine receptors, glutamate receptors, and noradrenaline transporters, but the CBF/ReHo correlated only with dopamine receptors. Importantly, the correlation coefficients between ReHo and dopamine receptors or noradrenaline transporters were associated with cognitive performance in COVID-19 survivors. Conversely, the correlation coefficients between CBF/ReHo and dopamine were correlated with depression in COVID-19 survivors.

Conclusion

COVID-19 survivors exhibit disruptions in local neural activity and NVC related to dopamine receptors and noradrenaline transporters. These alterations are associated with depression and cognitive impairment, suggesting a potential molecular basis for impaired neural and neurovascular function.
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