Yao Wang , Ziwei Yang , Xiao Liang , Lin Wu , Chengsi Wu , Jiankun Dai , Yuan Cao , Xianjun Zeng , Meng Li , Fuqing Zhou
{"title":"多巴胺受体和去甲肾上腺素转运蛋白相关的破坏与COVID-19幸存者的抑郁和认知表现有关","authors":"Yao Wang , Ziwei Yang , Xiao Liang , Lin Wu , Chengsi Wu , Jiankun Dai , Yuan Cao , Xianjun Zeng , Meng Li , Fuqing Zhou","doi":"10.1016/j.metrad.2025.100170","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to explore the relationships between neural activity, neurovascular coupling (NVC), and neurotransmitter receptors, and to investigate their association with emotion and cognition in COVID-19 survivors.</div></div><div><h3>Materials and methods</h3><div>A total of 42 COVID-19 survivors and 30 matched healthy controls (HCs) were recruited. Regional homogeneity (ReHo) and functional connectivity strength (FCS) were calculated -to assess local and global neural activity, respectively. Cerebral blood flow (CBF) was characterized as brain perfusion. Regional NVC was evaluated using CBF/ReHo and CBF/FCS ratios at the voxel level. Neurotransmitter receptor maps were derived from the JuSpace toolbox, which integrates positron emission tomography (PET) and single-photon emission computed tomography (SPECT) data from healthy populations. These maps included 16 receptor/transporters, such as dopamine, serotonin, norepinephrine and glutamate receptors, among others. Spatial correlations between neural activity, NVC and neurotransmitter receptor maps were subsequently analyzed in COVID-19 survivors.</div></div><div><h3>Results</h3><div>Whether examining neural activity or NVC, COVID-19 survivors primariily exhibiteddecreased ReHo or CBF/ReHo pattern compared to HC. Moreover, the neurotransmitter receptor distributions showed strong associations exclusively with local neural activity (e.g., ReHo) and NVC (e.g., CBF/ReHo) in COVID-19 survivors. Specifically, the spatial pattern of ReHo correlated with dopamine receptors, glutamate receptors, and noradrenaline transporters, but the CBF/ReHo correlated only with dopamine receptors. Importantly, the correlation coefficients between ReHo and dopamine receptors or noradrenaline transporters were associated with cognitive performance in COVID-19 survivors. Conversely, the correlation coefficients between CBF/ReHo and dopamine were correlated with depression in COVID-19 survivors.</div></div><div><h3>Conclusion</h3><div>COVID-19 survivors exhibit disruptions in local neural activity and NVC related to dopamine receptors and noradrenaline transporters. These alterations are associated with depression and cognitive impairment, suggesting a potential molecular basis for impaired neural and neurovascular function.</div></div>","PeriodicalId":100921,"journal":{"name":"Meta-Radiology","volume":"3 3","pages":"Article 100170"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dopamine receptor- and noradrenaline transporter-related disruptions are associated with depression and cognitive performance in COVID-19 survivors\",\"authors\":\"Yao Wang , Ziwei Yang , Xiao Liang , Lin Wu , Chengsi Wu , Jiankun Dai , Yuan Cao , Xianjun Zeng , Meng Li , Fuqing Zhou\",\"doi\":\"10.1016/j.metrad.2025.100170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>This study aims to explore the relationships between neural activity, neurovascular coupling (NVC), and neurotransmitter receptors, and to investigate their association with emotion and cognition in COVID-19 survivors.</div></div><div><h3>Materials and methods</h3><div>A total of 42 COVID-19 survivors and 30 matched healthy controls (HCs) were recruited. Regional homogeneity (ReHo) and functional connectivity strength (FCS) were calculated -to assess local and global neural activity, respectively. Cerebral blood flow (CBF) was characterized as brain perfusion. Regional NVC was evaluated using CBF/ReHo and CBF/FCS ratios at the voxel level. Neurotransmitter receptor maps were derived from the JuSpace toolbox, which integrates positron emission tomography (PET) and single-photon emission computed tomography (SPECT) data from healthy populations. These maps included 16 receptor/transporters, such as dopamine, serotonin, norepinephrine and glutamate receptors, among others. Spatial correlations between neural activity, NVC and neurotransmitter receptor maps were subsequently analyzed in COVID-19 survivors.</div></div><div><h3>Results</h3><div>Whether examining neural activity or NVC, COVID-19 survivors primariily exhibiteddecreased ReHo or CBF/ReHo pattern compared to HC. Moreover, the neurotransmitter receptor distributions showed strong associations exclusively with local neural activity (e.g., ReHo) and NVC (e.g., CBF/ReHo) in COVID-19 survivors. Specifically, the spatial pattern of ReHo correlated with dopamine receptors, glutamate receptors, and noradrenaline transporters, but the CBF/ReHo correlated only with dopamine receptors. Importantly, the correlation coefficients between ReHo and dopamine receptors or noradrenaline transporters were associated with cognitive performance in COVID-19 survivors. Conversely, the correlation coefficients between CBF/ReHo and dopamine were correlated with depression in COVID-19 survivors.</div></div><div><h3>Conclusion</h3><div>COVID-19 survivors exhibit disruptions in local neural activity and NVC related to dopamine receptors and noradrenaline transporters. These alterations are associated with depression and cognitive impairment, suggesting a potential molecular basis for impaired neural and neurovascular function.</div></div>\",\"PeriodicalId\":100921,\"journal\":{\"name\":\"Meta-Radiology\",\"volume\":\"3 3\",\"pages\":\"Article 100170\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Meta-Radiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950162825000384\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Meta-Radiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950162825000384","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dopamine receptor- and noradrenaline transporter-related disruptions are associated with depression and cognitive performance in COVID-19 survivors
Purpose
This study aims to explore the relationships between neural activity, neurovascular coupling (NVC), and neurotransmitter receptors, and to investigate their association with emotion and cognition in COVID-19 survivors.
Materials and methods
A total of 42 COVID-19 survivors and 30 matched healthy controls (HCs) were recruited. Regional homogeneity (ReHo) and functional connectivity strength (FCS) were calculated -to assess local and global neural activity, respectively. Cerebral blood flow (CBF) was characterized as brain perfusion. Regional NVC was evaluated using CBF/ReHo and CBF/FCS ratios at the voxel level. Neurotransmitter receptor maps were derived from the JuSpace toolbox, which integrates positron emission tomography (PET) and single-photon emission computed tomography (SPECT) data from healthy populations. These maps included 16 receptor/transporters, such as dopamine, serotonin, norepinephrine and glutamate receptors, among others. Spatial correlations between neural activity, NVC and neurotransmitter receptor maps were subsequently analyzed in COVID-19 survivors.
Results
Whether examining neural activity or NVC, COVID-19 survivors primariily exhibiteddecreased ReHo or CBF/ReHo pattern compared to HC. Moreover, the neurotransmitter receptor distributions showed strong associations exclusively with local neural activity (e.g., ReHo) and NVC (e.g., CBF/ReHo) in COVID-19 survivors. Specifically, the spatial pattern of ReHo correlated with dopamine receptors, glutamate receptors, and noradrenaline transporters, but the CBF/ReHo correlated only with dopamine receptors. Importantly, the correlation coefficients between ReHo and dopamine receptors or noradrenaline transporters were associated with cognitive performance in COVID-19 survivors. Conversely, the correlation coefficients between CBF/ReHo and dopamine were correlated with depression in COVID-19 survivors.
Conclusion
COVID-19 survivors exhibit disruptions in local neural activity and NVC related to dopamine receptors and noradrenaline transporters. These alterations are associated with depression and cognitive impairment, suggesting a potential molecular basis for impaired neural and neurovascular function.