树突状细胞的功能超越抗原呈递

IF 44.5 1区 医学 Q1 CELL BIOLOGY
Eynav Klechevsky
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引用次数: 0

摘要

在这一期的Cancer Cell中,Chen等人发现表达dnase1l3的树突状细胞(dc)是抗肿瘤免疫的增强剂。通过降解中性粒细胞胞外陷阱,这些dc促进CD8 + T细胞浸润到肿瘤中,增强检查点阻断效果,将DNASE1L3已知的免疫调节作用扩展到肿瘤微环境的物理重塑中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dendritic cells function beyond antigen presentation
In this issue of Cancer Cell, Chen et al. identify DNASE1L3-expressing dendritic cells (DCs) as enhancers of anti-tumor immunity. By degrading neutrophil extracellular traps, these DCs promote CD8⁺ T cell infiltration into tumors and enhance checkpoint blockade efficacy, extending DNASE1L3’s known immune regulatory role to physical remodeling of the tumor microenvironment.
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来源期刊
Cancer Cell
Cancer Cell 医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍: Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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