胃食管反流病相关肿瘤的内镜下粘膜剥离。

IF 1.2 4区 医学 Q3 SURGERY
Zhukai Chen, Zhuyun Leng, Jiacheng Xu, Kang Fang, Zehua Zhang, Jingjing Lian, Haibin Zhang, Li Zhang, Tao Chen, Meidong Xu
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引用次数: 0

摘要

背景与目的:胃食管反流病(GERD)是一种广泛流行的疾病,严重影响患者的生活质量,是已知的食管腺瘤和癌的危险因素。内镜下粘膜下剥离(ESD)是一种组织切除技术,包括对肿瘤周围的粘膜进行环周整体切除,然后对病变下的食管胃交界(EGJ)粘膜下层进行剥离。粘膜切除后,粘膜愈合导致瘢痕形成,瘢痕形成导致贲门瓣的收缩和重塑,从而理论上减少反流事件。本研究探讨了ESD治疗gerd相关肿瘤的安全性和有效性。方法:我们对2018年12月至2023年5月期间接受ESD治疗的96例gerd相关肿瘤患者的数据进行了回顾性分析。收集了临床、内镜、组织学和随访资料。结果:整体切除率为100%,完全切除率为99.0%,治愈性切除率为95.8%,主要并发症发生率为8.4%。在随访期间,所有患者均无局部复发和转移。6个月后胃食管反流症状持续缓解的患者比例为69.6%。切除的管腔周长比例是影响胃食管反流症状缓解的因素。结论:ESD治疗GERD相关肿瘤安全有效,且缓解GERD症状的可能性大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endoscopic Submucosal Dissection for Gastroesophageal Reflux Disease-Related Neoplasms.

Background and aim: Gastroesophageal reflux disease (GERD) is a widely prevalent disease that severely influences patients' quality of life and is a known risk factor for esophageal adenoma and carcinoma. Endoscopic submucosal dissection (ESD) is a tissue resection technique that involves circumferential en bloc resection of the mucosa that surrounds the tumor followed by dissection of the esophagogastric junction (EGJ) submucosa under the lesion. After mucosal resection, the mucosal healing results in scar formation, which in turn results in shrinkage and remodeling of gastric cardia flap valve, thereby theoretically reducing reflux events. This study investigated the safety and efficacy of ESD for GERD-related neoplasms.

Methods: We performed a retrospective analysis of data collected from 96 patients with GERD-related neoplasms treated with ESD between December 2018 and May 2023. Clinical, endoscopic, histologic, and follow-up data were collected.

Results: The overall rates of en bloc resection, complete resection, curative resection, and major complications were 100%, 99.0%, 95.8%, and 8.4%, respectively. During the follow-up period, all patients remained free from local recurrence and metastasis. The proportion of patients who remained alleviation of GERD symptom was 69.6% after 6 months. The proportion of the resected lumen circumference was the factor that affected the alleviation of GERD symptoms.

Conclusions: ESD is safe and effective for GERD-related neoplasms and is efficacious for the high probability of alleviation of GERD symptoms.

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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
103
审稿时长
3-8 weeks
期刊介绍: Surgical Laparoscopy Endoscopy & Percutaneous Techniques is a primary source for peer-reviewed, original articles on the newest techniques and applications in operative laparoscopy and endoscopy. Its Editorial Board includes many of the surgeons who pioneered the use of these revolutionary techniques. The journal provides complete, timely, accurate, practical coverage of laparoscopic and endoscopic techniques and procedures; current clinical and basic science research; preoperative and postoperative patient management; complications in laparoscopic and endoscopic surgery; and new developments in instrumentation and technology.
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