南非一家教学医院成人急性心力衰竭的临床特点和结局

IF 3.7 2区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Umar G. Adamu, Muzi Maseko, Nqoba Tsabedze
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引用次数: 0

摘要

目的:在撒哈拉以南非洲(SSA),基于左心室射血分数(LVEF)分类的成人急性心力衰竭(HF)的临床概况和住院结果尚不清楚。本研究旨在描述基于LVEF分类的急性心衰患者的患病率和临床特征及其与住院预后的关系。方法:在2023年2月至11月期间,246例连续的急性心衰患者被纳入这项前瞻性研究。将患者分为射血分数降低型HF (HFrEF)、轻度射血分数降低型HF (HFmrEF)和保留射血分数型HF (HFpEF)三类。主要结局指标为全因住院死亡率。对成年急性心衰患者各种LVEF表型的患病率和结果进行了评估。结果:患者平均年龄54.94±15.83岁,女性207例(51%),差异有统计学意义(P = 0.004)。257例(63.3%)HFrEF, 62例(15.3%)HFmrEF, 87例(21.4%)HFpEF。HFpEF患者年龄较大,以女性为主,总体纵向评分中位数较高,n端前b型利钠肽(NT-proBNP)水平较低(P结论:在我们的研究中,HFrEF是主要表型,每种表型都表现出不同的临床和生物标志物特征。全因住院死亡率较低,各表型间无显著差异。死亡率的独立预测指标包括炎症、电解质失衡和中重度AR。这些发现强调了有针对性的风险分层和管理策略的必要性,以改善这一人群的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical characteristics and outcomes of adults with acute heart failure in a South African teaching hospital

Clinical characteristics and outcomes of adults with acute heart failure in a South African teaching hospital

Aims

In sub-Saharan Africa (SSA), the clinical profile and in-hospital outcomes of adults with acute heart failure (HF) based on left ventricular ejection fraction (LVEF) categories are unknown. This study aimed to describe the prevalence and clinical characteristics of patients admitted with acute HF based on LVEF categories and their association with in-hospital outcomes.

Methods

Four hundred six consecutive patients with acute HF were enrolled in this prospective study between February and November 2023. The patients were stratified into three categories: HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF). The primary outcome measure was all-cause in-hospital mortality. The prevalence and outcomes of various LVEF phenotypes were evaluated in adult patients with acute HF.

Results

The mean age of the patients was 54.94 ± 15.83 years, of whom 207 (51%) were female (P = 0.004). Two hundred fifty-seven (63.3%) patients had HFrEF, 62 (15.3%) had HFmrEF, and 87 (21.4%) had HFpEF. Patients with HFpEF were older and predominantly female and had a higher median global longitudinal score and lower N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (P < 0.001). The all-cause in-hospital mortality was 3.4% [95% confidence interval (CI): 2.0–6.0] without significant variation across LVEF phenotypes (P = 0.70). In the multivariable model after adjusting for age and sex, higher C-reactive protein levels [odds ratio (OR): 1.02; 95% CI: 1.00–1.03; P = 0.009], elevated neutrophil–lymphocyte ratio (OR: 1.15; 95% CI: 1.03–1.29; P = 0.012), elevated serum potassium (OR: 3.41; 95% CI: 1.23–9.43; P = 0.018), moderate aortic regurgitation (AR) (OR: 12.80; 95% CI: 1.12–101.29; P = 0.016) and severe AR (OR: 34.49; 95% CI: 3.77–353.47; P = 0.002) were observed. Low diastolic blood pressure was associated with a reduced mortality risk (OR: 0.94; 95% CI: 0.89–0.99; P = 0.045).

Conclusions

In our study, HFrEF was the predominant phenotype, and each phenotype exhibited distinct clinical and biomarker profiles. All-cause in-hospital mortality was low and did not differ significantly across the phenotypes. Independent predictors of mortality included markers of inflammation, electrolyte imbalance and moderate-to-severe AR. These findings highlight the need for targeted risk stratification and management strategies to improve the outcomes in this population.

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来源期刊
ESC Heart Failure
ESC Heart Failure Medicine-Cardiology and Cardiovascular Medicine
CiteScore
7.00
自引率
7.90%
发文量
461
审稿时长
12 weeks
期刊介绍: ESC Heart Failure is the open access journal of the Heart Failure Association of the European Society of Cardiology dedicated to the advancement of knowledge in the field of heart failure. The journal aims to improve the understanding, prevention, investigation and treatment of heart failure. Molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, as well as the clinical, social and population sciences all form part of the discipline that is heart failure. Accordingly, submission of manuscripts on basic, translational, clinical and population sciences is invited. Original contributions on nursing, care of the elderly, primary care, health economics and other specialist fields related to heart failure are also welcome, as are case reports that highlight interesting aspects of heart failure care and treatment.
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