{"title":"CD34血管生成标志物在口腔鳞状细胞癌中的免疫组织化学研究","authors":"Vijayalaxmi, Sunil S Mishra, N C Sangamesh","doi":"10.4103/ccd.ccd_545_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis.</p><p><strong>Objectives: </strong>To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different histologic grades of oral squamous cell carcinoma (OSCC).</p><p><strong>Materials and methods: </strong>Sixty archival samples are categorized in four groups. Immunohistochemical method with anti-CD34 was used for analyzing MVD.</p><p><strong>Results: </strong>The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. Highly significant correlation is observed among different groups of OSCC samples.</p><p><strong>Conclusion: </strong>CD34 shows a promising result in OSCC.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"16 2","pages":"124-127"},"PeriodicalIF":1.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342217/pdf/","citationCount":"0","resultStr":"{\"title\":\"CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study.\",\"authors\":\"Vijayalaxmi, Sunil S Mishra, N C Sangamesh\",\"doi\":\"10.4103/ccd.ccd_545_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis.</p><p><strong>Objectives: </strong>To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different histologic grades of oral squamous cell carcinoma (OSCC).</p><p><strong>Materials and methods: </strong>Sixty archival samples are categorized in four groups. Immunohistochemical method with anti-CD34 was used for analyzing MVD.</p><p><strong>Results: </strong>The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. Highly significant correlation is observed among different groups of OSCC samples.</p><p><strong>Conclusion: </strong>CD34 shows a promising result in OSCC.</p>\",\"PeriodicalId\":10632,\"journal\":{\"name\":\"Contemporary Clinical Dentistry\",\"volume\":\"16 2\",\"pages\":\"124-127\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342217/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contemporary Clinical Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ccd.ccd_545_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary Clinical Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ccd.ccd_545_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
Background: Angiogenesis is recognized as a predominant factor for tumor growth and metastasis. Use of biomarkers to target tumor holds a promising treatment strategy and to assess prognosis.
Objectives: To assess angiogenic activity by analyzing CD34 microvascular density (MVD) count in different histologic grades of oral squamous cell carcinoma (OSCC).
Materials and methods: Sixty archival samples are categorized in four groups. Immunohistochemical method with anti-CD34 was used for analyzing MVD.
Results: The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. Highly significant correlation is observed among different groups of OSCC samples.
Conclusion: CD34 shows a promising result in OSCC.
期刊介绍：
The journal Contemporary Clinical Dentistry (CCD) (Print ISSN: 0976-237X, E-ISSN:0976- 2361) is peer-reviewed journal published on behalf of Maharishi Markandeshwar University and issues are published quarterly in the last week of March, June, September and December. The Journal publishes Original research papers, clinical studies, case series strictly of clinical interest. Manuscripts are invited from all specialties of Dentistry i.e. Conservative dentistry and Endodontics, Dentofacial orthopedics and Orthodontics, Oral medicine and Radiology, Oral pathology, Oral surgery, Orodental diseases, Pediatric Dentistry, Periodontics, Clinical aspects of Public Health dentistry and Prosthodontics. Review articles are not accepted. Review, if published, will only be by invitation from eminent scholars and academicians of National and International repute in the field of Medical/Dental education.
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