死亡神话：女性对急性肾损伤没有抵抗力。

IF 7.7 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical science Pub Date : 2025-08-13 DOI:10.1042/CS20257005

Brian Soto Miranda, Carmen De Miguel

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引用次数: 0

摘要

关于女性慢性肾脏疾病（CKD）患病率高于男性背后的机制，存在一个重要的知识缺口。大多数已发表的报告表明，女性可以避免急性肾损伤（AKI）和AKI到ckd的转变；然而，在这一期的《临床科学》中，Moronge等人证明，尽管血浆肌酐水平正常，雌性大鼠在缺血再灌注损伤后仍存在肾损伤的亚临床标志物。这些研究强调了aki诱导的亚临床损伤的潜力，这是女性在生命后期发展为CKD的更高敏感性的基础。

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The death of a myth: Females are not resistant to acute kidney injury.

There is an important gap of knowledge regarding the mechanisms behind the greater prevalence of chronic kidney disease (CKD) in females compared with males. Most of the published reports suggest that females are protected from acute kidney injury (AKI) and from the AKI-to-CKD transition; however, in this issue of Clinical Science, Moronge et al. demonstrate that female rats present with subclinical markers of kidney damage post-ischemic reperfusion injury despite normalized levels of plasma creatinine. These studies underscore the potential for this AKI-induced subclinical injury to underlie the higher sensitivity of females to develop CKD later in life.

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来源期刊

Clinical science 医学-医学：研究与实验

CiteScore

11.40

自引率

0.00%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively: Cardiovascular system Cerebrovascular system Gastrointestinal tract and liver Genomic medicine Infection and immunity Inflammation Oncology Metabolism Endocrinology and nutrition Nephrology Circulation Respiratory system Vascular biology Molecular pathology.