{"title":"基因组血统和其他传统危险因素对巴西1型糖尿病混合个体糖尿病周围神经病变患病率的影响：一项开创性的多中心研究","authors":"Cejana Hamu Aguiar, Hermelinda Cordeiro Pedrosa, Lucianne Righeti Monteiro Tannus, Livia Leite Ferreira, Dayse Silva, Luís Cristóvão Porto, Carlos Antonio Negrato, Marilia Brito Gomes","doi":"10.1111/jns.70049","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims</h3>\n \n <p>To assess the influence of genomic ancestry (GA) and other traditional risk factors on the prevalence of diabetic peripheral neuropathy (DPN) in admixed Brazilian individuals with type 1 diabetes (T1D).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cross-sectional, multicenter, pioneer study was conducted in 14 public clinics in 10 Brazilian cities. From 1760 individuals, 1732 were included (98.4%), aged 29.9 ± 11.9 years, diabetes duration 15.4 ± 9.2 years, 968 females (55.9%), 939 (55.7%) self-reported as White. DPN was evaluated by the validated neuropathy disability score (NDS) and neuropathy symptoms score (NSS).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The prevalence of DPN was 14.8%. In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health-related quality of life, presence of diabetic retinopathy, and amputations. Among the sociodemographic characteristics, African GA, a contemporary emerging factor, showed the highest association.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>DPN was related to several comorbidities, diabetes-related complications, and lower health-related quality of life. These individuals were young, implying a high lifetime cost of this disease. The association with the emerging factor African GA warrants further studies involving other admixed populations.</p>\n </section>\n </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 3","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70049","citationCount":"0","resultStr":"{\"title\":\"Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study\",\"authors\":\"Cejana Hamu Aguiar, Hermelinda Cordeiro Pedrosa, Lucianne Righeti Monteiro Tannus, Livia Leite Ferreira, Dayse Silva, Luís Cristóvão Porto, Carlos Antonio Negrato, Marilia Brito Gomes\",\"doi\":\"10.1111/jns.70049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>To assess the influence of genomic ancestry (GA) and other traditional risk factors on the prevalence of diabetic peripheral neuropathy (DPN) in admixed Brazilian individuals with type 1 diabetes (T1D).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This cross-sectional, multicenter, pioneer study was conducted in 14 public clinics in 10 Brazilian cities. From 1760 individuals, 1732 were included (98.4%), aged 29.9 ± 11.9 years, diabetes duration 15.4 ± 9.2 years, 968 females (55.9%), 939 (55.7%) self-reported as White. DPN was evaluated by the validated neuropathy disability score (NDS) and neuropathy symptoms score (NSS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The prevalence of DPN was 14.8%. In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health-related quality of life, presence of diabetic retinopathy, and amputations. Among the sociodemographic characteristics, African GA, a contemporary emerging factor, showed the highest association.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>DPN was related to several comorbidities, diabetes-related complications, and lower health-related quality of life. These individuals were young, implying a high lifetime cost of this disease. The association with the emerging factor African GA warrants further studies involving other admixed populations.</p>\\n </section>\\n </div>\",\"PeriodicalId\":17451,\"journal\":{\"name\":\"Journal of the Peripheral Nervous System\",\"volume\":\"30 3\",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70049\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Peripheral Nervous System\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jns.70049\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Peripheral Nervous System","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jns.70049","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study
Aims
To assess the influence of genomic ancestry (GA) and other traditional risk factors on the prevalence of diabetic peripheral neuropathy (DPN) in admixed Brazilian individuals with type 1 diabetes (T1D).
Methods
This cross-sectional, multicenter, pioneer study was conducted in 14 public clinics in 10 Brazilian cities. From 1760 individuals, 1732 were included (98.4%), aged 29.9 ± 11.9 years, diabetes duration 15.4 ± 9.2 years, 968 females (55.9%), 939 (55.7%) self-reported as White. DPN was evaluated by the validated neuropathy disability score (NDS) and neuropathy symptoms score (NSS).
Results
The prevalence of DPN was 14.8%. In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health-related quality of life, presence of diabetic retinopathy, and amputations. Among the sociodemographic characteristics, African GA, a contemporary emerging factor, showed the highest association.
Conclusions
DPN was related to several comorbidities, diabetes-related complications, and lower health-related quality of life. These individuals were young, implying a high lifetime cost of this disease. The association with the emerging factor African GA warrants further studies involving other admixed populations.
期刊介绍：
The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders.
The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies.
Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials.
The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.
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