神经活性类固醇有望成为创新麻醉剂

IF 4.2 4区 医学 Q2 CHEMISTRY, MEDICINAL
Lu Liu, Yubao Li, Tian Mao, Ting Li, Ruilou Zhu, Xuhui Cong, Lulu Jiang, Mingyang Sun, Jiaqiang Zhang
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引用次数: 0

摘要

先前的研究表明,全身麻醉剂对发育中的大脑有神经毒性作用。降低麻醉药的毒性或寻找无神经毒性的麻醉药是麻醉学研究的主要挑战。神经活性类固醇(Neuroactive steroids, NASs)是神经组织中调节神经系统兴奋性的活性类固醇,γ-氨基丁酸亚型A受体(γ-氨基丁酸亚型A receptor, GABAARs)在这一调节过程中起关键作用。NASs在麻醉中有许多优点,包括起效快、轻度心肺抑制和神经保护,特别是最近的研究表明NASs不会对发育中的大脑造成神经毒性。NASs有可能回到人类临床应用,从而协助临床麻醉。本文从NASs的作用靶点、药物特性、神经保护作用等方面探讨了NASs的应用前景,并重点分析了NASs在麻醉中不引起神经毒性的可能机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Neuroactive Steroids Hold Promise as Innovative Anesthetics

Neuroactive Steroids Hold Promise as Innovative Anesthetics

Neuroactive Steroids Hold Promise as Innovative Anesthetics

Previous studies have shown that general anesthetics have neurotoxic effects on developing brains. Reducing the toxicity of anesthetics or finding nonneurotoxic anesthetics is a major challenge in anesthetic research. Neuroactive steroids (NASs) are active steroids in nervous tissue that regulate the excitability of the nervous system, γ-Aminobutyric acid subtype A receptors (GABAARs) serve as key targets in this regulatory process. NASs have many advantages in anesthesia, including rapid onset, mild cardiopulmonary inhibition, and neuroprotection, especially in recent studies showing that NASs do not cause neurotoxicity in the developing brain. NASs have the potential to return to human clinical applications, thereby assisting in clinical anesthesia. This article discusses the application prospects of NASs from the perspectives of action targets, drug characteristics, and neuroprotective effects, with a particular analysis of the possible mechanisms by which NASs do not induce neurotoxicity in anesthesia.

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来源期刊
CiteScore
6.40
自引率
2.60%
发文量
104
审稿时长
6-12 weeks
期刊介绍: Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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