星形胶质细胞的性别特异性：从发育到进化的见解

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2025-08-13 DOI:10.1007/s11064-025-04512-w

Mariza Bortolanza, Davide Gobbo, Lipao Fang, Anja Scheller, Xianshu Bai, Frank Kirchhoff

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引用次数: 0

摘要

探索星形胶质细胞的性别特异性差异已成为神经生物学研究的一个重要领域。这项研究揭示了女性和男性的星形胶质细胞对神经元功能、整体大脑健康和各种神经系统疾病的贡献有何不同。这些细胞在维持体内平衡、提供代谢支持、促进神经递质循环和对中枢神经系统损伤作出反应方面发挥着关键作用。受性别、发育阶段、物种差异和环境条件等因素的影响，其生理表现出显著的变异性。这篇综述提供了这些因素的综合概述，涉及的关键主题包括发育动力学、衰老、信号机制、神经胶质相互作用、对病理状态的反应和跨物种比较。

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Sex-Specific Properties of Astrocytes: From Development to Evolutionary Insights

Exploring sex-specific differences in astrocytes has emerged as a vital area of neurobiological research. This research sheds light on how astrocytes in females and males differ in their contribution to neuronal functionality, overall brain health, and various neurological disorders. These cells play a critical role in sustaining homeostasis, providing metabolic support, facilitating neurotransmitter recycling and responding to injuries to the central nervous system. Their physiology exhibits significant variability, which is influenced by factors such as sex, developmental stage, species differences and environmental conditions. This review provides an integrated overview of these factors, addressing key themes including developmental dynamics, aging, signalling mechanisms, glial interactions, responses to pathological states and cross-species comparisons.

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.