纤维蛋白原-白蛋白比是膝关节置换术患者深静脉血栓形成的独立预测因子

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-08-09 DOI:10.1016/j.jor.2025.08.008

Chen Yan , Qian Wang , Xin Li

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引用次数: 0

摘要

深静脉血栓形成（DVT）是膝关节置换术（KA）后KA的常见并发症，可导致血栓后综合征（PTS）的发展。PTS与生活质量（QoL）下降和治疗费用增加有关。本研究旨在探讨纤维蛋白原与白蛋白比（FAR）与下肢深静脉血栓形成的相关性，并评价FAR对ka后深静脉血栓形成的预测价值。方法选取2020年8月至2022年8月在关节外科行KA的331例患者为研究对象。其中，术后常规彩色多普勒血流显像（CDFI）发现DVT患者38例为研究组，未发现DVT患者278例为对照组。分析术前FAR比率，探讨术前FAR与KA后下肢DVT的关系。结果两组患者的基本特征无明显差异。此外，在实验室值，包括白细胞、中性粒细胞、血红蛋白、纤维蛋白原、白蛋白和血小板，术前和术后无统计学差异。然而，DVT患者术前FAR明显高于对照组(0.077±0.007∶0.067±0.012,P <；0.001)。FAR预测下肢DVT的ROC曲线分析显示截断值为0.070 (AUC = 0.732, P <；0.001)，敏感性为94.7%，特异性为51.1%。多因素logistic回归分析显示术前FAR是ka后DVT的唯一独立预测因子(OR = 1.12, 95% CI: 1.06-1.17, P <；0.001)。结论术前FAR对ka后下肢DVT有较好的预测能力。它的检测可能是预测KA患者DVT的一种简单有效的方法。

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Fibrinogen-albumin-ratio is an independent predictor of deep vein thrombosis in patients undergoing knee arthroplasty

Background

Deep vein thrombosis (DVT) is a prevalent complication of KA following knee arthroplasty (KA), leading to the development of post-thrombotic syndrome (PTS). PTS is associated with declining quality of life (QoL) and increased treatment costs. This study aims to investigate the correlation between fibrinogen to albumin ratio (FAR) and lower extremity DVT and evaluate the predictive value of FAR in diagnosing DVT post-KA.

Methods

A total of 331 patients undergoing KA at the Department of Joint Surgery between August 2020 and August 2022 were included in this study. Among them,38 patients with DVT identified through post-operative routine color Doppler flow imaging (CDFI) comprised the study group, while 278 patients without DVT formed the control group. Pre-operative FAR ratios were analyzed to investigate the association between pre-operative FAR and lower extremity DVT following KA.

Results

No significant differences were observed in the basic characteristics between the two groups. Additionally, there were no statistically significant differences in the laboratory values, including white blood cells, neutrophils, hemoglobin, fibrinogen, albumin, and platelets before and after surgery. However, the pre-operative FAR in patients with DVT was significantly higher than that in the control group (0.077 ± 0.007 vs. 0.067 ± 0.012, P < 0.001). ROC curve analysis of FAR for predicting lower extremity DVT revealed a cut-off value of 0.070 (AUC = 0.732, P < 0.001), with a sensitivity of 94.7 % and specificity of 51.1 %. Multivariate logistic regression analysis showed pre-operative FAR was the only independent predictor of DVT post-KA (OR = 1.12, 95 %CI: 1.06–1.17, P < 0.001).

Conclusions

Pre-operative FAR has a good predictive capability for lower extremity DVT post-KA.Its detection may be a simple and useful method for the prediction of DVT in patients undergoing KA.

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.