肠道反应和肠道本能：受体胍基环化酶C （GC-C）对肠道稳态的调节。

IF 4.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Journal Pub Date : 2025-08-13 DOI:10.1042/bcj20253055

Avipsa Bose,Sandhya S Visweswariah

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引用次数: 0

摘要

肠道在指导和调节整个生物体的健康方面所起的重要作用不容低估。我们开始剖析肠道上皮细胞功能的内在分子，这些细胞反过来又控制着各种组织的反应。在这篇综述中，我们概述了受体胍基环化酶在调节肠道液体离子稳态、细胞增殖和微生物组中的作用。在新型小鼠模型和类器官培养的帮助下，进一步阐明分子细节，将增加我们对该受体和环鸟苷3',5'-单磷酸在先天性分泌性腹泻和炎症性肠病中的作用的理解。

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Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).

The important role that the gut plays in directing and modulating the well-being of the entire organism cannot be underestimated. We are beginning to dissect molecular players that are intrinsic to the functioning of the epithelial cells of the gut, which, in turn, control the responses of various tissues. In this review, we provide an overview of the role of a receptor guanylyl cyclase in regulating fluid-ion homeostasis, cell proliferation and the microbiome in the gut. Further elucidation of molecular details, aided by the development of novel mouse models and organoid cultures, should increase our understanding of the role of this receptor and cyclic guanosine 3',5'-monophosphate in congenital secretory diarrhoea and inflammatory bowel disease.

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来源期刊

Biochemical Journal 生物-生化与分子生物学

CiteScore

8.00

自引率

0.00%

发文量

255

审稿时长

1 months

期刊介绍： Exploring the molecular mechanisms that underpin key biological processes, the Biochemical Journal is a leading bioscience journal publishing high-impact scientific research papers and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences and molecular biology. The Journal and its Editorial Board are committed to publishing work that provides a significant advance to current understanding or mechanistic insights; studies that go beyond observational work using in vitro and/or in vivo approaches are welcomed. Painless publishing: All papers undergo a rigorous peer review process; however, the Editorial Board is committed to ensuring that, if revisions are recommended, extra experiments not necessary to the paper will not be asked for. Areas covered in the journal include: Cell biology Chemical biology Energy processes Gene expression and regulation Mechanisms of disease Metabolism Molecular structure and function Plant biology Signalling