{"title":"组织驻留记忆T细胞（TRMs）在疾病和疫苗开发中的作用：综述","authors":"Hongyu Wei, Yunfeng Wang, Shichun Jiang, Xiaoli Zhang, Jinyong Zhang","doi":"10.1016/j.vaccine.2025.127605","DOIUrl":null,"url":null,"abstract":"<p><p>Tissue-resident memory T cells (TRMs) are integral to localized immune defense, characterized by their capacity for long-term tissue residency and rapid effector responses in infectious diseases. Beyond their established roles in antimicrobial immunity, TRMs exhibit unique therapeutic potential in tumor immunology and vaccine design. This review summarizes the advances in TRM biology, emphasizing molecular determinants of tissue residency, functional specialization across tissue niches, and mechanistic insights into pathogen-specific immunity. We highlight the roles of TRMs in cancer and their critical function in combating infections, including viral, bacterial, and parasitic challenges. Furthermore, we critically evaluate vaccine strategies leveraging TRM biology, such as mucosal delivery, adjuvant modulation, and antigen persistence engineering, to enhance protective immunity. Addressing challenges like interspecies discrepancies in TRM longevity and exhaustion dynamics will be pivotal for translating these insights into durable vaccine platforms against infectious diseases and cancer.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"62 ","pages":"127605"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The roles of tissue-resident memory T cells (TRMs) in diseases and vaccine development: A comprehensive review.\",\"authors\":\"Hongyu Wei, Yunfeng Wang, Shichun Jiang, Xiaoli Zhang, Jinyong Zhang\",\"doi\":\"10.1016/j.vaccine.2025.127605\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tissue-resident memory T cells (TRMs) are integral to localized immune defense, characterized by their capacity for long-term tissue residency and rapid effector responses in infectious diseases. Beyond their established roles in antimicrobial immunity, TRMs exhibit unique therapeutic potential in tumor immunology and vaccine design. This review summarizes the advances in TRM biology, emphasizing molecular determinants of tissue residency, functional specialization across tissue niches, and mechanistic insights into pathogen-specific immunity. We highlight the roles of TRMs in cancer and their critical function in combating infections, including viral, bacterial, and parasitic challenges. Furthermore, we critically evaluate vaccine strategies leveraging TRM biology, such as mucosal delivery, adjuvant modulation, and antigen persistence engineering, to enhance protective immunity. Addressing challenges like interspecies discrepancies in TRM longevity and exhaustion dynamics will be pivotal for translating these insights into durable vaccine platforms against infectious diseases and cancer.</p>\",\"PeriodicalId\":94264,\"journal\":{\"name\":\"Vaccine\",\"volume\":\"62 \",\"pages\":\"127605\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vaccine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.vaccine.2025.127605\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.vaccine.2025.127605","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/10 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
The roles of tissue-resident memory T cells (TRMs) in diseases and vaccine development: A comprehensive review.
Tissue-resident memory T cells (TRMs) are integral to localized immune defense, characterized by their capacity for long-term tissue residency and rapid effector responses in infectious diseases. Beyond their established roles in antimicrobial immunity, TRMs exhibit unique therapeutic potential in tumor immunology and vaccine design. This review summarizes the advances in TRM biology, emphasizing molecular determinants of tissue residency, functional specialization across tissue niches, and mechanistic insights into pathogen-specific immunity. We highlight the roles of TRMs in cancer and their critical function in combating infections, including viral, bacterial, and parasitic challenges. Furthermore, we critically evaluate vaccine strategies leveraging TRM biology, such as mucosal delivery, adjuvant modulation, and antigen persistence engineering, to enhance protective immunity. Addressing challenges like interspecies discrepancies in TRM longevity and exhaustion dynamics will be pivotal for translating these insights into durable vaccine platforms against infectious diseases and cancer.
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