膝关节骨关节炎患者接受透明质酸注射后的严重急性局部反应/假性脓毒症：一项有针对性的文献综述。

IF 1.2 4区医学 Q3 ORTHOPEDICS

Orthopedics Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI:10.3928/01477447-20250715-01

Seth Lawrence Sherman, Wilson Ngai, Kevin Steele, Jean-Paul Collet, John D A Kelly

{"title":"膝关节骨关节炎患者接受透明质酸注射后的严重急性局部反应/假性脓毒症：一项有针对性的文献综述。","authors":"Seth Lawrence Sherman, Wilson Ngai, Kevin Steele, Jean-Paul Collet, John D A Kelly","doi":"10.3928/01477447-20250715-01","DOIUrl":null,"url":null,"abstract":"Background: Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC®).Materials and methods: Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections.Results: The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection.Conclusion: Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.","PeriodicalId":19631,"journal":{"name":"Orthopedics","volume":" ","pages":"305-314"},"PeriodicalIF":1.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Severe Acute Localized Reaction/Pseudosepsis in Patients With Knee Osteoarthritis Receiving Injections of Hyaluronic Acid: A Targeted Literature Review.\",\"authors\":\"Seth Lawrence Sherman, Wilson Ngai, Kevin Steele, Jean-Paul Collet, John D A Kelly\",\"doi\":\"10.3928/01477447-20250715-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC®).Materials and methods: Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections.Results: The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection.Conclusion: Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.\",\"PeriodicalId\":19631,\"journal\":{\"name\":\"Orthopedics\",\"volume\":\" \",\"pages\":\"305-314\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Orthopedics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/01477447-20250715-01\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orthopedics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/01477447-20250715-01","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

摘要

背景：膝骨关节炎患者注射透明质酸可导致假性脓毒症。我们进行了一项有针对性的文献综述，以确定接受关节内透明质酸，特别是hylan G-F 20 （SYNVISC®）治疗的患者的假性脓毒症发生率。材料和方法：通过Embase使用预定义的搜索策略对文章进行识别。假性脓毒症事件发生率通过报告事件数除以关节内注射总次数来计算。结果：假性脓毒症发生率为0% ~ 5.6%；大多数治疗组每次注射的事件发生率≤2%。结论：在所有研究中，使用透明质酸（包括hylan g - f20）治疗的患者的假性脓毒症发生率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Severe Acute Localized Reaction/Pseudosepsis in Patients With Knee Osteoarthritis Receiving Injections of Hyaluronic Acid: A Targeted Literature Review.

Background: Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC^®).

Materials and methods: Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections.

Results: The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection.

Conclusion: Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Orthopedics 医学-整形外科

CiteScore

2.20

自引率

0.00%

发文量

160

审稿时长

3 months

期刊介绍： For over 40 years, Orthopedics, a bimonthly peer-reviewed journal, has been the preferred choice of orthopedic surgeons for clinically relevant information on all aspects of adult and pediatric orthopedic surgery and treatment. Edited by Robert D''Ambrosia, MD, Chairman of the Department of Orthopedics at the University of Colorado, Denver, and former President of the American Academy of Orthopaedic Surgeons, as well as an Editorial Board of over 100 international orthopedists, Orthopedics is the source to turn to for guidance in your practice. The journal offers access to current articles, as well as several years of archived content. Highlights also include Blue Ribbon articles published full text in print and online, as well as Tips & Techniques posted with every issue.