Ru（II）在空气条件下催化2-酰基咪唑与tips -炔或tips -溴炔的直接炔化反应

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-08-12 DOI:10.1039/d5qo00868a

Yuting Gui, Xingchi Li, Ting Fu, Taoyuan Liang, Zequan Li, Shuangliang Zhao, Zhuan Zhang

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引用次数: 0

摘要

报道了Ru（II）催化的2-酰基咪唑的正炔化反应，证明了与tips保护的末端炔或tips保护的溴炔作为炔化试剂的相容性。该反应可耐受多种官能团，所得到的炔基化产物可以很容易地转化为高价值化合物，在药物化学和材料科学方面具有广阔的应用前景。该策略通过提出烷基化反应通过六元钌环中间体进行来解决现有的差距。

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Ru(II)-Catalyzed Direct Alkynylation of 2-Acylimidazoles with TIPS-Alkynes or TIPS-Bromoalkynes under Air

The Ru(II)-catalyzed ortho-alkynylation of 2-acylimidazoles is reported, demonstrating compatibility with TIPS-protected terminal alkynes or TIPS-protected bromoalkynes as alkynylating reagents. The reaction tolerates a wide range of functional groups, and the resulting alkynylated products can be readily transformed into high-value compounds, presenting promising applications in medicinal chemistry and materials science. This strategy addresses the existing gap by proposing that the alkynylation reaction proceeds through six-membered ruthenacycle intermediates.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.