{"title":"在流行病威胁的背景下对孕产妇和围产期健康结果进行系统审查:拟订一套核心结果。","authors":"Agustina Mazzoni, Mabel Berrueta, Veronica Pingray, Magdalena Babinska, Carolina Nigri, Vanesa Ortega, Florencia Salva, Agustín Ciapponi, Mercedes Bonet","doi":"10.1186/s40748-025-00215-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To systematically identify and classify maternal and perinatal health outcomes reported in research conducted in the epidemic and pandemic context.</p><p><strong>Study design and setting: </strong>We conducted a systematic review following Cochrane Methods. We searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov and ICTRP, between January 2015 and March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, and post-marketing studies, published protocols and ongoing registered studies reporting maternal and perinatal health outcomes were included. Studies only reporting coverage of interventions, access to routine health services, clinical presentation of infectious diseases, and reviews were excluded. A sampling strategy was used for COVID-19 studies, due to their very high numbers. Outcome verbatims were extracted and categorized in unique outcome, and further classified into domains and subdomains. Frequency of outcome reporting was calculated.</p><p><strong>Results: </strong>94 maternal and pregnancy and 47 unique neonatal outcomes were identified, from a total of 917 and 657 verbatims, respectively, reported across 440 included studies. At least 20% of included studies reported maternal and pregnancy outcomes of mode of delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders of pregnancy (26.6%), and maternal death (20.7%). These outcomes were identified across all three types of studies identified (epidemiological, product development or post-authorization surveillance). Gestational age at birth (29.8%), congenital malformations of the nervous system (26.1%), birth weight (23.4%), neonatal admission to intensive care unit (23.2%), and neonatal death (19.1%) were the most frequently reported neonatal outcomes.</p><p><strong>Conclusions: </strong>Our study provides the basis for developing a core outcome set to measure maternal and perinatal health during outbreaks, which would help improve data collection of harmonized data, data synthesis, and timely development of informed public health guidance and clinical care responding to the needs of pregnant women.</p>","PeriodicalId":74120,"journal":{"name":"Maternal health, neonatology and perinatology","volume":"11 1","pages":"23"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337472/pdf/","citationCount":"0","resultStr":"{\"title\":\"A systematic review of maternal and perinatal health outcomes in the context of epidemic threats: towards the development of a core outcome set.\",\"authors\":\"Agustina Mazzoni, Mabel Berrueta, Veronica Pingray, Magdalena Babinska, Carolina Nigri, Vanesa Ortega, Florencia Salva, Agustín Ciapponi, Mercedes Bonet\",\"doi\":\"10.1186/s40748-025-00215-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To systematically identify and classify maternal and perinatal health outcomes reported in research conducted in the epidemic and pandemic context.</p><p><strong>Study design and setting: </strong>We conducted a systematic review following Cochrane Methods. We searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov and ICTRP, between January 2015 and March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, and post-marketing studies, published protocols and ongoing registered studies reporting maternal and perinatal health outcomes were included. Studies only reporting coverage of interventions, access to routine health services, clinical presentation of infectious diseases, and reviews were excluded. A sampling strategy was used for COVID-19 studies, due to their very high numbers. Outcome verbatims were extracted and categorized in unique outcome, and further classified into domains and subdomains. Frequency of outcome reporting was calculated.</p><p><strong>Results: </strong>94 maternal and pregnancy and 47 unique neonatal outcomes were identified, from a total of 917 and 657 verbatims, respectively, reported across 440 included studies. At least 20% of included studies reported maternal and pregnancy outcomes of mode of delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders of pregnancy (26.6%), and maternal death (20.7%). These outcomes were identified across all three types of studies identified (epidemiological, product development or post-authorization surveillance). Gestational age at birth (29.8%), congenital malformations of the nervous system (26.1%), birth weight (23.4%), neonatal admission to intensive care unit (23.2%), and neonatal death (19.1%) were the most frequently reported neonatal outcomes.</p><p><strong>Conclusions: </strong>Our study provides the basis for developing a core outcome set to measure maternal and perinatal health during outbreaks, which would help improve data collection of harmonized data, data synthesis, and timely development of informed public health guidance and clinical care responding to the needs of pregnant women.</p>\",\"PeriodicalId\":74120,\"journal\":{\"name\":\"Maternal health, neonatology and perinatology\",\"volume\":\"11 1\",\"pages\":\"23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337472/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Maternal health, neonatology and perinatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40748-025-00215-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Maternal health, neonatology and perinatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40748-025-00215-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:系统地识别和分类在流行病和大流行背景下进行的研究中报告的孕产妇和围产期健康结果。研究设计和背景:我们采用Cochrane方法进行了系统评价。我们检索了MEDLINE、EMBASE、LILACS、SCI-EXPANDED、CINAHL、Cochrane Central Register of Controlled Trials、PsycINFO、AMED、ClinicalTrials.gov和ICTRP,检索时间为2015年1月至2023年3月。包括实验性、准实验性、观察性研究、IV期试验、上市后研究、已发表的方案和正在进行的报告孕产妇和围产期健康结果的注册研究。仅报告干预措施覆盖面、获得常规保健服务、传染病临床表现和审查的研究被排除在外。由于COVID-19研究的数量非常多,因此采用了抽样策略。结果逐字提取并分类为唯一结果,并进一步分类为域和子域。计算结果报告的频率。结果:在440项纳入的研究中,分别从总共917和657个单词中确定了94个孕产妇和妊娠以及47个独特的新生儿结局。至少20%的纳入研究报告了分娩方式(56.1%)、死胎(33.0%)、早产(28.6%)、妊娠高血压疾病(26.6%)和孕产妇死亡(20.7%)的孕产妇和妊娠结局。这些结果是在所确定的所有三种类型的研究(流行病学、产品开发或授权后监督)中确定的。出生时胎龄(29.8%)、先天性神经系统畸形(26.1%)、出生体重(23.4%)、新生儿入住重症监护病房(23.2%)和新生儿死亡(19.1%)是最常见的新生儿结局。结论:我们的研究为制定一套核心结果集提供了基础,以衡量疫情期间的孕产妇和围产期健康状况,这将有助于改善统一数据的数据收集、数据综合,并及时制定符合孕妇需求的知情公共卫生指导和临床护理。
A systematic review of maternal and perinatal health outcomes in the context of epidemic threats: towards the development of a core outcome set.
Objective: To systematically identify and classify maternal and perinatal health outcomes reported in research conducted in the epidemic and pandemic context.
Study design and setting: We conducted a systematic review following Cochrane Methods. We searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov and ICTRP, between January 2015 and March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, and post-marketing studies, published protocols and ongoing registered studies reporting maternal and perinatal health outcomes were included. Studies only reporting coverage of interventions, access to routine health services, clinical presentation of infectious diseases, and reviews were excluded. A sampling strategy was used for COVID-19 studies, due to their very high numbers. Outcome verbatims were extracted and categorized in unique outcome, and further classified into domains and subdomains. Frequency of outcome reporting was calculated.
Results: 94 maternal and pregnancy and 47 unique neonatal outcomes were identified, from a total of 917 and 657 verbatims, respectively, reported across 440 included studies. At least 20% of included studies reported maternal and pregnancy outcomes of mode of delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders of pregnancy (26.6%), and maternal death (20.7%). These outcomes were identified across all three types of studies identified (epidemiological, product development or post-authorization surveillance). Gestational age at birth (29.8%), congenital malformations of the nervous system (26.1%), birth weight (23.4%), neonatal admission to intensive care unit (23.2%), and neonatal death (19.1%) were the most frequently reported neonatal outcomes.
Conclusions: Our study provides the basis for developing a core outcome set to measure maternal and perinatal health during outbreaks, which would help improve data collection of harmonized data, data synthesis, and timely development of informed public health guidance and clinical care responding to the needs of pregnant women.