Tutkun Talih, Gokhan Sonmez, Erdogan M Sozuer, Sevket Tolga Tombul, Mahmut O Kulturoglu, Dogan G Islam, Hızır Y Akyıldız, Abdullah Demirtas, Mustafa Karaagac, Fatih Dal
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The secondary endpoint, considering all the patients, is to evaluate and investigate the risk factors affecting the AL rates.</p><p><strong>Results: </strong>A total of 178 patients, including 63 (35.4%) patients in Group 1 and 115 (64.6%) patients in Group 2, were included in the study. The mean age of all patients was 61.7 ± 9.9 years, and there was no statistical difference between the mean ages of the groups (62.8 ± 11.3 vs 60.7 ± 6.1, p = 0.106, respectively). Thirty-six (20.2%) of the patients were female, and 142 (79.8%) were male. There was no significant difference between the groups in terms of AL in the postoperative period. Postoperative AL was seen in three patients (4.8%) and six patients (5.2%) in Group 1 and Group 2, respectively (p = 0.642). According to univariate and multiple logistic regression analysis, the risk of AL increased in patients with comorbidities, in the presence of previous abdominal surgery, in patients with high neutrophil-to-lymphocyte ratio, and patients with postoperative ileus (p values are 0.042, 0.010, 0.029 and 0.048, respectively).</p><p><strong>Conclusion: </strong>Our data suggest that anastomosis due to colon cancer resection does not increase the risk of AL compared with healthy bowel anastomoses. In addition, some clinical factors have been found to compromise anastomotic safety and are risk factors for AL. 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引用次数: 0
摘要
目的:评价癌性和非癌性肠吻合口的吻合口瘘发生率,分析发生吻合口瘘的一般危险因素。本研究的主要目的是探讨原发性结肠癌患者行乙状结肠切除术+结直肠吻合术(1组)与结直肠区域完全健康的患者行乙状结肠切除术+结直肠吻合术用于膀胱根治性前列腺切除术(2组)在AL方面是否存在差异。考虑到所有患者,次要终点是评估和调查影响AL发生率的危险因素。结果:共纳入178例患者,其中1组63例(35.4%),2组115例(64.6%)。患者平均年龄为61.7±9.9岁,两组平均年龄(62.8±11.3 vs 60.7±6.1,p = 0.106)比较,差异无统计学意义。其中女性36例(20.2%),男性142例(79.8%)。两组术后AL无明显差异。1组术后AL发生率为3例(4.8%),2组术后AL发生率为6例(5.2%)(p = 0.642)。单因素和多元logistic回归分析显示,合并合并症、有腹部手术史、中性粒细胞/淋巴细胞比值高、术后肠梗阻患者发生AL的风险增加(p值分别为0.042、0.010、0.029、0.048)。结论:我们的数据表明,与健康的肠吻合术相比,结肠癌切除术后的吻合术不会增加AL的风险。此外,一些临床因素已经发现危及吻合口安全性,是AL的危险因素。另外,一些临床因素已经发现危及吻合口安全性,是AL的危险因素。
Risk Factors for Sigmoid Colonic Anastomosis: A Comparative and Cross-Sectional Analysis.
Objective: To evaluate the anastomotic leakage (AL) rates in cancerous and non-cancerous intestinal anastomoses and analyze the general risk factors for AL.
Methods: The primary endpoint of this study is to investigate whether there is a difference in terms of AL between patients who underwent sigmoid colon resection + colorectal anastomosis due to primary colon cancer (Group 1) and patients with a completely healthy colorectal region who underwent sigmoid colon resection + colorectal anastomosis for use in the orthotopic bladder during radical cystoprostatectomy (Group 2). The secondary endpoint, considering all the patients, is to evaluate and investigate the risk factors affecting the AL rates.
Results: A total of 178 patients, including 63 (35.4%) patients in Group 1 and 115 (64.6%) patients in Group 2, were included in the study. The mean age of all patients was 61.7 ± 9.9 years, and there was no statistical difference between the mean ages of the groups (62.8 ± 11.3 vs 60.7 ± 6.1, p = 0.106, respectively). Thirty-six (20.2%) of the patients were female, and 142 (79.8%) were male. There was no significant difference between the groups in terms of AL in the postoperative period. Postoperative AL was seen in three patients (4.8%) and six patients (5.2%) in Group 1 and Group 2, respectively (p = 0.642). According to univariate and multiple logistic regression analysis, the risk of AL increased in patients with comorbidities, in the presence of previous abdominal surgery, in patients with high neutrophil-to-lymphocyte ratio, and patients with postoperative ileus (p values are 0.042, 0.010, 0.029 and 0.048, respectively).
Conclusion: Our data suggest that anastomosis due to colon cancer resection does not increase the risk of AL compared with healthy bowel anastomoses. In addition, some clinical factors have been found to compromise anastomotic safety and are risk factors for AL. In addition, some clinical factors have been found to endanger anastomotic safety and are risk factors for AL.
期刊介绍:
Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas.
The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature.
As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication.
The journal does not accept study protocols, animal-based or cell line-based studies.