遗传多态性作为卡铂和紫杉醇治疗妇科恶性肿瘤的治疗生物标志物：系统综述。

IF 3.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Clinical therapeutics Pub Date : 2025-10-01 DOI:10.1016/j.clinthera.2025.07.012

Nadine de Godoy Torso MSc , Yasmim Gabriele Matos PharmB , Giovana Fernanda Santos Fidelis BPharm , Carolina Dagli-Hernandez PhD , Marília Berlofa Visacri PhD , Eder de Carvalho Pincinato PhD , Jefman Efendi Marzuki MD , Baharuddin Baharuddin MSc , Paulo Caleb J.L. Santos PhD , Patricia Moriel PhD

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引用次数: 0

摘要

目的：妇科肿瘤是影响女性生殖系统的一类肿瘤，具有较高的发病率和死亡率。本系统综述旨在总结与这些患者卡铂-紫杉醇化疗临床结果相关的药物遗传变异的最新进展。方法：对8个数据库进行全面的文献检索，以确定截至2024年7月17日发表的研究。两名审稿人独立选择研究并提取数据；分歧由另外两名审稿人解决。发现：在发现的2375条记录中，只有20条符合资格标准。主要发现：(1)研究最多的3个基因是ATP结合盒亚家族C成员1 （ABCB1）、细胞色素P450 2C8 （CYP2C8）和谷胱甘肽s转移酶P1 (GSTP1)；(2) rs1128503 （ABCB1）、rs10509681和rs11572080 （CYPC28）这三个变体似乎与重要的药物不良反应（特别是中性粒细胞减少症、血小板减少症和周围感觉神经病变）有显著关联。其他基因，如rs1045642 （ABCB1）和rs1695 (GSTP1)，结果不一致，这些结果可以外推的程度仍然有限；(c)大多数纳入的研究涉及亚洲或欧洲患者。意义：因此，未来的研究应该包括更广泛的分析和更具包容性的队列。由于研究的局限性，由于研究之间存在显著的异质性，因此无法进行荟萃分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genetic Polymorphisms as Treatment Biomarkers for Gynecological Malignancies Treated With Carboplatin and Paclitaxel: A Systematic Review

Purpose

Gynecological tumors, which correspond to the group of neoplasms that affect the female reproductive system, have high incidence and mortality rates. This systematic review aimed to summarize the most recent advances in identifying pharmacogenetic variants associated with the clinical outcomes of carboplatin-paclitaxel chemotherapy in these patients.

Methods

A comprehensive literature search was conducted across eight databases to identify studies published up to July 17, 2024. Two reviewers independently selected the studies and extracted the data; disagreements were resolved by two additional reviewers.

Findings

Out of the 2375 records that were found, only 20 met the eligibility criteria. The main findings were: (1) The three most extensively investigated genes were ATP binding cassette subfamily C member 1 (ABCB1), cytochrome P450 2C8 (CYP2C8), and glutathione S-transferase P1 (GSTP1); (2) three variants, rs1128503 (ABCB1), rs10509681 and rs11572080 (CYPC28), appear to have a significant association with important adverse drug reactions (in particular, neutropenia, thrombocytopenia, and peripheral sensory neuropathy). Others, as is the case with rs1045642 (ABCB1) and rs1695 (GSTP1), have inconsistent results, and the extent to which these results can be extrapolated is still limited; and (c) most of the included studies concerned Asian or European patients.

Implications

Therefore, future research should include more extensive analyses with more inclusive cohorts. As a limitation of the study, a meta-analysis was not possible due to the significant heterogeneity among the studies.

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.