脊髓损伤的中枢模式产生：机制、调节和运动恢复的治疗策略

IF 3.9 3区医学 Q1 ORTHOPEDICS

JOR Spine Pub Date : 2025-08-11 DOI:10.1002/jsp2.70100

Hao Su, Longfei Jing, Dongmei Lv, Zhendong Huan, Wenqiang Xu

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引用次数: 0

摘要

脊髓损伤（SCI）损害了参与运动的大脑和脊髓回路之间的通信，导致严重的运动功能障碍。然而，目前可用的治疗方法在恢复脊髓损伤后的运动功能方面效果有限。最近的研究强调了中枢模式发生器（CPG）在运动恢复中的重要性，CPG是一种在没有脑源性输入时负责产生腿部运动活动协调模式的脊髓回路。因此，对于脊髓损伤后的恢复性治疗，一个非常有希望的方法是重新激活CPG网络，以利用其节律性活动产生能力。各种形式的神经调节，如药理学，电刺激和基于光的调节策略，已被用于这一目的。结果总结了CPG网络的组织结构和功能特征，研究了脊髓损伤后CPG的变化，并评估了通过CPG再激活恢复运动功能的神经调节策略的最新进展。本综述还强调了该领域存在的挑战，并概述了未来研究的展望方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

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Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

Background

Spinal cord injury (SCI) compromises the communication between the brain and spinal circuits involved in locomotion, resulting in severe motor dysfunction. However, currently available therapies have limited effectiveness in restoring motor function after SCI.

Objective

Recent research has highlighted the importance of the central pattern generator (CPG), a spinal circuitry responsible for generating coordinated patterns of leg motor activity in the absence of brain-derived inputs, in locomotor recovery. Therefore, a highly promising approach for restorative treatment after SCI involves reactivating the CPG network to harness its rhythmic activity-generating capabilities. Various forms of neuromodulation, such as pharmacological agents, electrical stimulation, and light-based regulatory strategies, have been utilized for this purpose.

Results

This review summarizes the organizational structure and functional characteristics of CPG networks, examines CPG alterations following SCI, and evaluates recent advances in neuromodulation strategies aimed at restoring motor function through CPG reactivation.